摘要
目的探讨子宫腺瘤样瘤的临床、病理特点。方法针对1406例因子宫平滑肌瘤切除子宫病例的临床资料和病理切片,对符合子宫腺瘤样瘤诊断的病例进行免疫组化观察与病理分析。结果 1406例子宫平滑肌瘤中检出子宫腺瘤样瘤26例,占同期子宫切除标本的1.85%,肿瘤多位于子宫浆膜下,直径0.6～5.5cm,临床表现与平滑肌瘤相似。显微镜下肿瘤以形成不规则腺样或裂隙样结构,内衬扁平或立方上皮为特点,伴有不同程度的平滑肌组织增生。肿瘤细胞AB-PAS染色阳性,免疫组化HBME-1、MC、Vimentin、广谱CK、Calretinin呈阳性表达,CEA、CD34和F8呈阴性表达。结论子宫腺瘤样瘤临床表现缺乏特异性,易误诊为平滑肌瘤,但二者常伴发,病理检查时多处取材,仔细观察,结合免疫组化可避免误诊,治疗首选手术切除,预后好,不复发,不转移。
Objective To discuss the clinical manifestation and pathological features of adenomatoid tumor of uterus. Methods The clinical data and pathological section of 1406 cases with uterine leiomyoma and performed IHC on cases with adenomatoid tumor of uterus were reviewed. Results 26 of 1406 were found adenomatoid tumor of uterus, ac-counting for 1.85% of hysterectomy in corresponding time. The tumor, 0. 6cm-5.5 cm in diameter, occurs in uterine serous layer usually. The clinical characters are similar to those of leiomyoma. Irregular glandular or/and fractured structures are deteced under microscope, with squamous epithelium or cuboidal epithelium inner lined and hyperplasia of smooth muscle cells in various degrees. AB-PAS dyeing is positive. The IHC indicate positive of HBME-1, MC, Vimen- tin, broadspectrum CK, Calretinin, while negative of CEA, CD34 and F8. Conclusion Clinical presentation of adenomatold tumor of uterus is usually idiopathic, thus easily make it misdiagnosed as leiomyoma which often intermingled with the former. More pathological sampling, closer inspection combined with IHC may avoid misdiagnose. Surgical remove is of first choice, with good prognosis, without recurrence and metastasis.
出处
《西部医学》
2013年第5期740-741,744,共3页
Medical Journal of West China
关键词
子宫腺瘤样瘤
临床特征
病理特征
Adenomatoid tumor of uterus
Clinical features
Pathological features
