摘要
目的观察不同剂量布地奈德混悬液雾化吸入治疗小儿毛细支气管炎的临床疗效。方法对分别给予布地奈德混悬液0.5mg/次(低剂量组)与1mg/次(高剂量组)雾化吸入治疗的80例毛细支气管炎患儿的临床资料进行分析比较。结果①1mg组30、60分钟临床评分显著低于0.5mg组,差异有统计学意义(P<0.01或P<0.001)。②1mg组30、60分钟呼吸频率显著低于0.5mg组,差异有统计学意义(P<0.01或P=0.05)。③1mg组30、60分钟氧饱和度显著高于0.5mg组,差异有统计学意义(P<0.001或P<0.01)。④1mg组平均住院时间、平均住院费用显著低于0.5mg组,差异有统计学意义(P<0.001)。⑤1mg组与0.5mg组雾化吸入均无明显不良反应。结论 1mg布地奈德混悬液雾化吸入治疗小儿毛细支气管炎与0.5mg相比,更能显著降低患儿在吸入治疗后30、60min的临床评分、呼吸频率,改善患儿氧饱和度,并缩短患儿的住院时间,降低住院费用。患儿雾化吸入布地奈德治疗无明显不良反应。
Objective To evaluate the clinical feature of pediatric patients with bronehiolitis, and compare their treatment response between different dosage of nebulised Budesonide Suspension for Inhalation. Methods The data of the children diagnosed and administrated between 2011.1-2011.5 were collected and analyzed by soft ware SPSS 19.0. The patients were randomly divided into 0. 5mg group（nebulised Budesonide Suspension for Inhalation 0.5mg once）and lmg group（nebulised Budesonide Suspension for Inhalation ling once）. The clinical score,respiratory frequency,oxygen saturation, length of stay, the cost were evaluated. Results 30 minutes after the treatment, The clinical score in ling group（6. 28± 1.16）was statistically lower than that（6.91±1.03） in the 0.5mg group（P= 0. 007）, the respiratory frequency in lmg group（55.7±7.1）was statistically lower than that（60. 23±6.2）in the 0. 5mg group（P=0. 003）, the oxygen saturation in lmg group （ 96.7 ±2.5 %） was statistically higher than that （ 94.3 ±1.8 %） in the 0. 5mg group （P〈0. 001 ）. 60 minutes after the treat, The clinical score in 1 mg group（5.14±1.58） was statistically lower than that（6.25.± 1.37） in the 0. 5rag group（P＇（0. 001）, the respiratory frequency in lmg group（51.5 ±7. 3）was statistically lower than that（55.3d： 6.4） in the 0. 5mg group（P= 0. 016）, the oxygen saturation in lmg group（97.2 ± 2. 6%） was statistically higher than that（95.6±2.3 % ）in the 0. 5mg group （P= 0. 004）the length of stay in l mg group（6.42±1.89） was statisti- cally shorter than that（8. 71±2.53） in the 0.5mg group（P〈0. 001）, the cost of hospitalization in lmg group（2142±164%）was statistical cheaper than that（2573-＋-189±）in 0.5mg group（P〈0. 001）. Conclusion The treatment response of the patients with bronchiolitis in ling group are better than that in 0.5mg group, These include faster changing in clinical score,respiratory frequency, oxygen saturation; shorter hospital day and less cost.
出处
《西部医学》
2013年第5期681-684,共4页
Medical Journal of West China
关键词
布地奈德混悬液
毛细支气管炎
疗效
different dosage
Budesonide Suspension for Inhalation
Bronchiolitis efficacy
