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肺炎链球菌中青霉素结合蛋白PBP3的功能与结构研究进展 被引量：2

Research on Structures and Functions of Penicillin-binding Protein 3 of Streptococcus pneumonia
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摘要 PBP3作为肺炎链球菌唯一的D,D羧肽酶,能够从肽聚糖五肽上移除最后一个末端D-Ala,导致转肽反应中供体不可用,因此控制了肽聚糖的网状交联水平,在细胞分裂和生长中起重要作用。文中对PBP3的功能与结构进行了综述,为今后PBP3的深入研究与应用提供了基础资料。 As the single D-Ala,D-Ala(D,D)-carboxypeptidase in Streptococcus pneumonia,PBP3 plays a key role in cell division and growth by trimming the last residue of pentapeptides to reduce the availability of donors for the transpeptidation reaction and thus limits the reticulation of the peptidoglycan.The structure and functions of PBP3 was reviewed,which will provide basic data for deep research and application of PBP3.
作者 周宇 王长振 侯粲 李爽跃 杨曙明
机构地区 中国农业科学院农业质量标准与检测技术研究所 军事医学科学院放射与辐射医学研究所
出处 《安徽农业科学》 CAS 2013年第8期3319-3322,共4页 Journal of Anhui Agricultural Sciences
基金 公益性行业科技专项(201203023)
关键词 青霉素结合蛋白PBP3 肺炎链球菌 结构与功能 PBP3 Streptococcus pneumonia Structure and function
分类号 S188 [农业科学—农业基础科学]
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参考文献32

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安徽农业科学
2013年 第8期

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