摘要
目的:探讨肺癌组织Med19和Ki-67蛋白相关性研究及临床意义。方法:采用免疫组化实验对50例肺癌患者组织中Med19和Ki-67蛋白表达进行检验。结果:癌周边组织Med19与癌组织内部表达具有统计学差异,以细胞核着色为主,阳性表达率超过80%。另外,研究发现Med19蛋白表达与肺癌患者分期、淋巴结转移具有相关性。结论:Med19与Ki-67表达呈现相关性,并关系到肺癌的发展和增殖,作为潜在癌基因在癌症进展中起到一定作用。
Objective：To explore the clinical significance of Med 19 protein in non-small cell lung cancer（NSCLC） and its relationship with Ki-67 expression.Methods：Med 19 and Ki-67 protein expression from lung tissues of 50 NSCLC patients were detected by immunphistochemical method.Results： There was hardly any Med 19 protein expression in tissues around cancer tissues.By contrast,intensity of Med 19 protein expression in cancer tissues was increased significantly,mainly in cell nuclei coloring which indicated that Med 19 protein expression was associated with lung tumorigenesis.There was relationship among Med 19 protein expression and clinical stage and lymph node metastasis of NSCLC patients.No correlation was found among Med 19 protein expression and the other clinical pathology parameters,such as age,gender pathological type and tissue stages.The expression of Med 19 was positive correlated with the expression of Ki-67.Conclusions：Med 19 may play an important role in progression of lung cancer as a potential oncogene and become a novel therapeutic target.
出处
《海南医学院学报》
CAS
2013年第6期772-774,777,共4页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210668)~~
