摘要
目的:观察急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)术后予以左卡尼汀治疗的临床疗效。方法:在我院住院的60例急性心肌梗死行PCI术后的患者,随机分为观察组和对照组,对照组予以抗凝及抗缺血治疗,观察组在常规治疗的基础上加用左卡尼汀。检测术前及术后肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白T(cTnT)、脑钠肽(BNP)水平,术前及术后2周心脏B超检查。结果:左卡尼汀组CK-MB、cTnT及血浆BNP水平较对照组下降明显,差异有统计学意义(P<0.05);心脏指数(CI)、左室射血分数(LVEF)治疗后均较对照组有明显改善,差异具有统计学意义(P<0.05)。结论:左卡尼汀对心肌具有保护作用,对急性心肌梗死PCI术后的患者使用具有重要的临床意义。
Objective： To observe the effects of left-carnitine in patients with acute myocardial infarction（AMI） after undergoing percutaneous coronary intervention（PCI）.Methods： A total of 60 patients with AMI underwent PCI were randomly divided into observation group and treatment group,Both groups were given conventional anticoagulant and anti-ischemic therapy,while the treatment group was also given extra left-carnitine.The concentration of creatine kinase（CK-MB）,troponin（cTnT）,brain natriuretic peptide（BNP） were detected before and after undergoing PCI.Ultrasonic cardiogram were conducted in both groups.Results： The level of CK-MB,cTnT,BNP of the treatment group were decreased after undergoing PCI comparing with the control group（P0.05）.LVEF and CI were improved and were better than that of the control group（P0.05）.Conclusion：Left-carnitine has cardio protection effects and can be used in patients with AMI after undergoing PCI.
出处
《海南医学院学报》
CAS
2013年第6期750-752,共3页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210659)~~
关键词
左卡尼汀
急性心肌梗死
直接经皮冠状动脉介入术
Left-carnitine
Acute myocardial infarction
Percutaneous coronary intervention
