摘要
目的：通过与传统控制心室率的药物去乙酰毛花苷注射液进行对比,探讨胺碘酮注射液对老年快速型心房颤动患者的临床疗效。方法：选择2010年5月~2012年6月我院急诊科收治的老年快速房颤患者60例,按就诊先后顺序随机分为对照组与胺碘酮治疗组,每组30例。胺碘酮治疗组患者先给予胺碘酮注射液150 mg以生理盐水稀释后缓慢静脉注射,继以0.5 mg/min静滴;对照组患者先予去乙酰毛花苷注射液0.2 mg稀释后缓慢静脉推注,若20 min无效则再次给药,两组患者的院内观察周期均为24h,患者在观察过程中行全程心电监护,观察不同时间段（用药后0、0.5、2、12、24 h）患者的心室率,血压的变化;比较两种治疗方法的临床疗效及对患者复律情况的影响。结果：治疗前,两组患者的心室率比较无显著性差异（P〉0.05）;第一次用药后0.5 h,两组患者的心室率都较治疗前显著下降（P〈0.01）,且用乙酰毛花苷注射液治疗的对照组显著低于胺碘酮治疗组（P〈0.05）;用药后2和12h,两组患者的心室率比较均无显著性差异（P〉0.05）;用药后24h,胺碘酮治疗组患者的心室率较对照组显著降低（P〈0.01）。对照组的临床有效率为40.0%,复律率为16.7%;而胺碘酮治疗组的临床有效率为73.3%,复律率为43.3%,分别显著高于对照组（P〈0.01）。与用药前比较,用药后0.5、2、12和24h患者的收缩压略有下降,但差异均无统计学意义（P〉0.05）。结论：与去乙酰毛花苷注射液比较,胺碘酮注射液可更有效地降低老年患者24 h心室率,复律率和有效率更高,但在应用过程中需注意其不良反应。
Objective： To investigate the effect of Amiodarone on elderly patients with atrial fibrillation through comparing with the effect of Lanatoside C.Methods： Sixty elderly patients with atrial fibrillation admitted in the emergency ward of our hospital（from 2010.5 to 2012.6） were randomly divided into two groups according to the visiting sequence,the control group and the Amiodarone group,thirty patients in each group.The patients in Amiodarone group were first given 150 mg amiodarone injection slowly via intravenous injection,the Amiodarone injection was diluted with saline followed by 0.5 mg/min infusion.The patients in control group were first given 0.2 mg Lanatoside C injection,if ineffective after 20min,the given 0.2 mg Lanatoside C injection once again via intravenous.The observing time of all the patients was 24 h.During the observing time,the patients were processed line full ECG,blood pressure monitoring.The ventricular rate and the systolic blood pressure were recorded at 0,0.5,2,12,24 h after the drugs were given;the clinical effects and the auricular fibrillation situation were also observed.Results： There was no significant difference of the ventricular rate between two groups before therapy（P0.05）.0.5 h after the drugs injection for the first time,the ventricular rate both decreased significantly in the two groups（P0.01）,which was lower in the control group than in the Amiodarone group（P0.05）.2 h and 12 h after the drugs injection,there was no significant difference of ventricular rate between two groups（P0.05）.but at the end of 24 h after therapy for the first time,the ventricular rate of Amiodarone group was lower than that of the Lanatoside C group（P0.01）.There were significant differences in both clinical efficiency（40.0% vs 73.3%） and cardioversion rate（16.7% vs 43.3） between the two therapy methods（P0.01）.Compared with before therapy,the systolic blood pressure decreased slightly 0.5 h,2 h,12 h and 24 h after the drugs injection（P0.05）.Conclusion： Compared with the Lanatoside C injection,Amiodarone injection may be more effective in reducing the 24 h ventricular rate of the elderly patients with atrial fibrillation,and had higher clinical effect rate and auricular fibrillation,but adverse reactions should be paid attention to during the treatment.
出处
《现代生物医学进展》
CAS
2013年第13期2557-2561,共5页
Progress in Modern Biomedicine
关键词
快速房颤
胺碘酮
乙酰毛花苷
老年患者
Rapid atrial fibrillation
Amiodarone
Lanatoside C
Elderly patients
