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在青岛汉族人群中INSIG1rs9769826单核苷酸多态性与血糖水平有关,与血脂水平无关(英文) 被引量：1

The INSIG1 rs9769826 Single Nucleotide Polymorphisms is Associated with the Fasting Glucose, but not with the Blood Lipids, in Qingdao Han-Chinese
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摘要 目的:探讨青岛汉族人群中INSIG1rs9769826单核苷酸多态性与血糖和血脂的关系。方法:随机选取217名年龄在35-86岁健康的青岛汉族居民作为受试者。应用聚合酶链式反应-限制片段长度多态性检测技术(PCR-RFLP)对INSIG1基因rs9769826多态性进行基因分型,用协方差分析的方法分析rs9769826多态性与血糖和血脂的关系。结果:INSIG1基因rs9769826位点AAAG GG基因型的频率分别为70.04%,36.73%和3.23%,INSIG1基因rs9769826多态性与空腹血糖水平之间差异有显著意义(P<0.001),与血脂水平差异无显著意义。结论:INSIGIrs9769826突变基因G与空腹血糖升高有关。 Objective： To investigate the relationship between rs9769826 single nucleotide polymorphisms of INSIG1 gene and fasting glucose and blood lipids in Qingdao Han-Chinese.Methods： 217 healthy residents aged 35-86 years old in Qingdao were randomly selected.The rs9769826 polymorphism of INSIG1 gene was genotyped by using the polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） method and the associations with fasting glucose and blood lipids were analyzed with the analysis of covariance.Results： The frequencies of AA,AG and GG genotypes were 70.04 %,36.73 % and 3.23 %,respectively.There was a significant association between INSIG1 rs9769826 single nucleotide polymorphisms and the fasting plasma glucose（P0.001）,while there was no significant relationship between rs9769826 single nucleotide polymorphisms and the blood lipids levels.Conclusion： The risk allele（＂G＂） was associated with a higher level of the fasting plasma glucose.
作者 胡平 张庆燕 王桂凤 张东峰
机构地区 青岛大学医学院公共卫生学院
出处 《现代生物医学进展》 CAS 2013年第13期2429-2432,共4页 Progress in Modern Biomedicine
基金 Natural Science Foundation of Shandong Province(ZR2010HM100)~~
关键词 INSIG1 Rs9769826 空腹血糖 血脂 INSIG1 Rs9769826 The fasting plasma glucose The blood lipids
分类号 Q75 [生物学—分子生物学] Q78 [生物学—分子生物学]
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参考文献21

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现代生物医学进展
2013年 第13期

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