摘要
目的:探讨缬沙坦联合阿托伐他汀钠对维持性血液透析患者炎症因子及其营养状况的影响。方法:将120例维持性血液透析患者随机分为对照组与观察组,每组各60例。给予对照组患者口服阿托伐他汀,观察组患者给予缬沙坦联合阿托伐他汀钠口服。比较两组治疗前后C-反应蛋白(CRP)、IL-6、肿瘤坏死因子(TNF-α)、抵抗素及血清白蛋白(ALb)、血红蛋白(Hb)的变化情况。结果:治疗后6月两组患者hs-CRP、TNF-α、IL-6及抵抗素水平均显著下降(P<0.05),但观察组患者上述指标显著低于对照组(P<0.05);观察组治疗后Alb及Hb水平显著高于对照组,差别具有统计学意义(P<0.05)。结论:缬沙坦联合阿托伐他汀钠用于维持性血液透析患者,可显著减少炎症因子水平,改善患者营养状况。
Objective： To investigate the effect of valsartan combined with atorvastatin on inflammatory factors and nutritional status in patients with maintenance hemodialysis. Methods： 120 cases with maintenance hemodialysis were randomly divided into control group and experimental group with 60 patients in each group. Cases in the control group were given oral atorvastatin while cases in the experience group received valsartan combined with atorvastatin treatment. Hs-CRP, IL-61 TNF-a, resistin, Alb and Hb before and after treatment were compared. Results： Hs-CRP, IL-6, TNF-a and resistin level after＇ treatment decreased more greatly than those before treatment in two groups （P〈0.05）; But the indexes were much lower in the experience group than the controls （P〈0.05）; Alb and Hb after treatment were much higher in experience （P〈0.05）. Conclusion： Valsartan combined with atorvastatin for patients with maintenance hemodialysis can greatly decrease the inflammatory factors level and improve the nutritional status.
出处
《现代生物医学进展》
CAS
2013年第12期2349-2351,共3页
Progress in Modern Biomedicine
