摘要
例1,男,61岁。因＂颈肩结节伴红肿4个月余,发热1周＂于2011年9月3日收入院。体检：贫血貌。颈肩可见数个不规则褐色斑块,约2cm×2cm大小,平皮面。皮肤结节病理检查（2011-08-09）：考虑（高分化）鳞癌。皮肤结节病理检查（2011-08-18）：未见肿瘤细胞。血常规（2011-09-03）：白细胞计数37.0×10^9/L,中性粒细胞0,淋巴细胞0,
Case one：a 61-year-old male patient was admitted because of ＂neck and shoulder nodules for more than 4 months and fever for one week＂. Physical examination showed several brown plaques in the neck and shoulder, paralleling to the skin. Lab examinations showed that WBC was 37.0×10^9/L, of which monocytes accounted for 5.90/oo（2.2×10^9/L）. Microscopy of whole blood showed blasts accounted for 10%. Bone marrow cell examina tion showed hypoplasia,with 77. 6% granulocytes,1.2% of which were blasts,and 5. 6% monoeytes,0.8% of which were promonocytes. Flow cytometric analysis showed myeloid blast accounted for 1. 73% of the whole karyocytes. Leukemia fusion gene CBFyMYH11 was positive. The patient was diagnosed as acute myeloid Ieuke mia （CBFβ/MYH11 positive）. Case two：a 62 year old male patient was admitted because of ＂jaundiced and palpitation after activities for more than half a month＂. Physical examination showed several enlarged, soybean-sized lymph nodes in bilateral inguinal region without tenderness. Lab examinations showed that white blood cell （WBC） count was 19.6 ×10^9/L, of which neutrophils accounted for 78.6 % （15.4 ×10^9/L） and lymphocytes accounted for 17.8 %. Bone marrow cell examination showed hyperplasia,with 95.5 % granulocytes,8.5 % of which were blasts,and 8.0 % were progranulocytes with Auer body. Flow cytometric analysis showed 5.36 % of the whole karyocytes were suspicious myeloid blasts. Leukemia fusion gene AML1/ETO was positive. The patient was diagnosed as acute myeloid leukemia （AML1/ETO positive）.
出处
《临床血液学杂志》
CAS
2013年第3期335-337,共3页
Journal of Clinical Hematology
