摘要
目的探讨血清同型半胱氨酸水平变化与高血压伴冠心病的关系。方法选取高血压患者132例(其中伴冠心病者60例)和健康体检者50例(对照组),采集所有研究对象空腹血,测定同型半胱氨酸、总胆固醇、三酰甘油、叶酸和维生素B12水平,此外测量身高、体质量及血压。结果三组研究对象空腹血糖比较,差异无统计学意义(P>0.05);高血压伴与不伴冠心病组患者血压水平显著高于对照组(P<0.01);高血压伴与不伴冠心病组患者血脂水平也高于对照组(P<0.05);高血压伴与不伴冠心病组患者叶酸和维生素B12水平低于对照组(P<0.05);高血压伴与不伴冠心病组患者血清同型半胱氨酸水平高于对照组(P<0.05);且高血压伴冠心病组患者血清同型半胱氨酸水平显著高于高血压不伴冠心病组(P<0.01)。结论高同型半胱氨酸血症与高血压伴冠心病的发生密切相关,是高血压伴冠心病的独立危险因素之一。
Objective To explore the relationship between the change of serum homocysteine（Hcy） and primary hypertension.Methods 136 patients with essential hypertension including 60 cases of complicating coronary heart disease and 50 healthy people as control group were selected.The fasting blood was collected for detecting the levels of Hcy,total cholesterol,triglyceride,folic acid and vitamin B12,and the body heights,body mass and blood pressure were also measured.Results There were no statistical difference in fasting glucose levels among the three groups（P〈0.05）;blood pressure levels in essential hypertension with and without coronary heart disease groups were significanly higher than that in the control group（P〈0.01）;the blood lipid levels in essential hypertension with and without coronary heart disease groups were higher than that in the control group（P〈0.05）;the folic acid and vitamin B12 levels in essential hypertension with and without coronary heart disease groups were lower than those in the control group（P〈0.05）;the serum Hcy levels in the essential hypertension with and without coronary heart disease groups were higher than that in the control group（P〈0.05）,and the serum Hcy level in the essential hypertension with coronary heart disease group was highest（P〈0.01）.Conclusion Hyperhomocysteinemia is closely related with the occurrence of coronary heart disease and one of the independent risk factors of coronary heart disease.
出处
《现代医药卫生》
2013年第9期1308-1309,共2页
Journal of Modern Medicine & Health
关键词
高血压
冠心病
高半胱氨酸
Hypertension
Coronary heart disease
Homocysteine
