摘要
目的：探讨P-糖蛋白在细胞癌组织中表达及临床意义。方法：采用免疫组化法对72例肝细胞癌，9例正常肝组织进行P-糖蛋白测定，作相关临床因素分析。结果：肝细胞癌组织中P-糖蛋白的阳性表达率为44．0％，正常肝组织表达率为22．0％（P＜0．05）。P-糖蛋白的表达与肝癌的组织分型、分级及预后无明显相关性，并且化疗并不影响p-糖蛋白阳性表达病人的预后。结论：P-糖蛋白在肝细胞癌中的过表达，提示其在肝细胞癌对化疗不敏感特性中起重要作用。
Objective: To study the clinical significance of P-glycoprotein(Pgp) expression in hepatocellular carcinoma(HCC). Methods: The expression of P-gp was studied immunohistochemically in 72 HCC and 9 normal liver tissues. Results: The positive rate of P-gp expression in HCC was 44.0%, but only 22.2% in normal liver tissue(P < 0.05) .There was no significance correlation between expression of Pgp and HCC grade, HCC type and prognosis and chemothrapy had no effect on survival time of P-gp positive patients. Conclusion: The authors may come to the conclusion that P-glycoprotein probably plays and improtant role in the poor response of HCC to chemotherapeutic agents .
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2000年第7期372-374,共3页
Chinese Journal of Immunology
基金
吉林省教委基金!9850
关键词
肝细胞癌
P-糖蛋白
多药耐药性
Hepatocellular carcinoma P-glycoprotein Multidrug resistance
