摘要
目的评价奥拉西坦联合长春西汀治疗脑梗死患者恢复期轻度认知功能障碍的疗效及安全性。方法选择90例脑梗死患者恢复期轻度认知功能障碍患者,随机分为3组,每组30例。各组均给予相同的基础药物治疗外,A组予奥拉西坦每次800mg,每日2次口服;B组予长春西汀20~30mg加入500ml液体内缓慢滴注;C组予奥拉西坦联合长春西汀,用法同A组和B组;三组疗程均为12w。治疗前后分别做简易精神状态量表（MMSE）、日常生活自理量表（ADL）检测,评价其疗效,并进行安全性评价。结果三组认知功能在治疗前差别无显著性（P〉0.05）,治疗12周后均较治疗前有提高（P〈0.05）,其中C组改善更显著（P〈0.01）,与另两组相比,差别有显著性（P〈0.05）。结论奥拉西坦联合长春西汀治疗脑梗死患者恢复期轻度认知功能障碍有较好的疗效及安全性。
Objective To estimate the efficacy and safety of oxiracetam combined with vinpocetine in the treatment of cerebral infarction patients.Methods 90 patients with cerebral infarction and mild cognitive dysfunction,were randomly devided into three groups, each group 30 cases. Patients of A group were given oxiracetam（800mg/d）,bid ;Patients of B group were given vinpocetine ,20～30mg added to 500ml of liquid drip slowly ;C group were oxiracetamjoint vinpocetine, usage of the same group A and group B; The course of treatment inthe three groups was 12 weeks. The mini-mental state examination （MMSE） and activities of daily living scale （ADL） were detected before and after the treatment to evaluate the efficacy and safety evaluation.Results There was no significant difference in the three groups（P〉0.05）, 12 weeks of treatment improved （P〈0.05）, where C group improved much more than the other two groups （P〈0.01）,the difference was significant （P〈O.OS）.Conclusion Oxiracetam combined with. vinpocetine proved to be effective in the treatment of mild cognitive impairment in patients with convalescence and cerebral infarction.
出处
《现代诊断与治疗》
CAS
2013年第3期494-495,共2页
Modern Diagnosis and Treatment
关键词
脑梗死
轻度认知功能障碍
奥拉西坦
长春西汀
Cerebral infarction
Mild cognitive dysfunction
Oxiracetam
Vinpocetine
