摘要
目的探讨抗反逆转录病毒治疗（HAART）对HIV阳性孕妇的影响。方法选取2005年1月～2010年12月在我院行母婴阻断接受HAART的HIV阳性孕妇107例为研究组,随机选取同期在广州市某医院产科HIV阴性孕妇135例为对照组。对孕妇的肝功能、血常规、生化指标等临床资料进行回顾性分析。根据接受HAART治疗时间不同分为HAART治疗1组（〈12w）、2组（12～36w）及3组（≥36w）,比较相关指标在研究组与对照组的差别。结果研究组的WBC均数为7.39±2.20×109/L、RBC均数为3.08±0.49×1012/L、Hb均数为101.87±12.75g/L、GLB均数为30.68±4.86g/L、空腹Glu均数为4.15±0.91mmol/L与对照组比较,差异有显著性意义（P〈0.05）;研究组AST升高等级与对照组比较,差异有显著性意义（χ2=6.29,P〈0.05）;PLT、TBil、ALT等级、TG、TC等指标差异无显著性意义（P〉0.05）。根据接受HAART时间对研究组再分3组,3组组间差异有统计学意义（P〉0.05）。1组与2组比较,WBC、RBC差异有统计学意义（P〉0.05）;1组与3组比较,RBC、Hb、GLB差异有统计学意义（P〉0.05）;2组与3组比较,Hb、GLB差异有统计学意义（P〉0.05）。根据是否感染肝炎病毒对所有观察案例进行分组,感染组与非感染者比较,肝功能分级差异有显著性意义（χ2=13.51,P〈0.01）。结论短期应用HAART药物对HIV阳性孕妇是安全的,在营养和肝功能没有明显的影响。接受HAART〈12w的HIV阳性孕妇应注意监测血常规,及时调整治疗方案及对症处理。
Objective To investigate influence of highly active antiretroviral therapy （HAART）on HIVinfected pregnant women by retrospectiving study method.Methods 115 pregnant women identifiedwith HIV infected and their newborn babies were analyzed as study group in our hospital from January 2005 to December 2010. All the pregnants had accepted antiretroviral drugs for blockade of HIV moth-er-to-child transmission. 135 HIV negative pregnant women and their newborns were chosen at random in a hospital of Guangzhou city as control group. Based on the time of HAART,patients in study groupwere divided into three groups between which the differences were analyzed.Results There were statistic significant differences between WBC, RBE, Hb, GLB, AST and CD4 count of study group and control group （P〈0.05）.While there were no significant differences between their hemoglobin, albumin, glucose, total cholesterOl and triglyceride （P〉0.05）.In study group,there was a statistic difference betweenWBC,RBC of group 1 and group 2, so were RBC, Hb, GLB of group 1 and group 3 and Hb, GLB of group 1 and group 3. All cases were divided into two groups according to hepatitis virus-infected ornot. Statistic difference of liver function level in the two groups was found. Conclusion Short-time HAART is safe to HIV-infected pregnant women with no influence on nutritional state and liver function. In cases which had accepted HAART less than 12 weeks, regular blood test and prompt and relative treatment should be given.
出处
《现代诊断与治疗》
CAS
2013年第3期483-485,共3页
Modern Diagnosis and Treatment
基金
广东省医学科研基金(A2009549)
广州市医药卫生科技项目(2008-YB-076)
关键词
HIV
高效抗反转录病毒治疗
孕妇
影响
副作用
HIV
Highly active antiretroviral therapy
Pregnant woman
Influence
Adverse effect
