摘要
目的了解甲状腺住院患者医院感染病原菌类型及药敏结果,为临床合理用药提供依据。方法采用法国生物梅里埃公司生产的Vitek-2全自动微生物分析系统鉴定分离菌,药敏试验采用K-B纸片法。结果 2010年12月～2011年12月共收治甲状腺疾病住院患者共201例,医院感染45例,感染率22.39%,检出病原菌42株。其中革兰阴性菌22株,以大肠埃希菌(11株)和肺炎克雷伯菌(8株)为主;革兰阳性菌18株,以粪肠球菌(9株)和表皮葡萄球菌(6株)为主;真菌2株,均为白色假丝酵母菌。分离菌对常用抗菌药物耐药率较高,仅对亚胺培南和阿米卡星敏感。感染治疗中一联用药占71.11%;医院感染治疗总有效率为80.00%。结论根据临床科室的病原菌类型及历史耐药情况制定抗菌治疗方案有助于提高医院感染的治愈率。
Objectives To investigate the types of pathogens responsible for nosocomial infections and their drug resist- ance in patients with a thyroid condition and to provide a basis for clinical rational drug use. Methods The BioMerieux Vitek-2 （France） bacteria identification system was used for bacterial identification. A drug sensitivity test was performed with paper strips. Results A total of 201 patients with a thyroid condition were treated from December 2010 to Decem- ber 2011; of these, 45 developed a nosocomial infection. A total of 42 strains of pathogenic bacteria were isolated, inclu- ding 22 strains of Gram-negative bacteria, 18 strains of Gram-positive bacteria, and 2 strains of fungi. There were 11 strains of Escherichia coli, 8 of Klebsiella pneurnoniae, 9 of Enterococcus faecalis, and 6 of Staphylococcus epiderrni- dis. The isolated pathogenic bacteria were resistant to most antibiotics and only susceptible to imipenem and amikacin. The rate of single antimicrobial usage was 71.11 % and total efficacy was 80.00%. Conclusion The types of pathogens and their drug resistance should be considered by specific departments when formulating an antimicrobial treatment plan in order to increase the rate at which nosocomial infections are cured.
出处
《中国病原生物学杂志》
CSCD
北大核心
2013年第4期363-364,共2页
Journal of Pathogen Biology
关键词
甲状腺
住院患者
医院感染
病原菌
耐药性
Thyroid
inpatient
nosocomial infection
pathogens
drug resistance
