摘要
【目的】探讨2型糖尿病患者中医体质特点及与胰岛素抵抗、分泌的关系,并说明各体质特点与相关危险因素的联系。【方法】通过运用流行病学的调研方法,对147例2型糖尿病患者进行问卷调查,分析其体质分布特点,并探讨各体质特点与胰岛素抵抗及胰岛素分泌功能的关系,同时对不同体质特点的糖尿病患者危险因素进行分析,探讨其相关性。【结果】2型糖尿病患者的主要体质类型为阴虚质(24.49%),其他依次为血瘀质(14.29%)、气虚质(12.93%)、痰湿质(12.24%)、平和质(8.84%)、阳虚质(6.80%)、湿热质(10.20%)、气郁质(6.12%)、特禀质(4.08%),阴虚质与其他体质类型比较,差异均有统计学意义(P<0.01)。胰岛素抵抗指数(IRI)痰湿质水平最高,胰岛素敏感指数(ISI)痰湿质水平最低,与其他各体质类型比较,差异均有统计学意义(P<0.01);胰岛β细胞功能(Homa-β)阴虚质水平最低,与其他各体质类型比较,差异均有统计学意义(P<0.05或P<0.01)。同时,各体质类型患者的糖尿病危险因素如吸烟、饮酒、体质量指数(BMI)、腰臀比(WHR)及空腹血糖(FPG)、空腹C肽(C-P)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、血脂、炎症因子等均有统计学差异(P<0.05或P<0.01)。【结论】2型糖尿病患者的体质类型与胰岛素抵抗指数、胰岛素敏感指数等均具有一定的关系。
Objective To investigate the the characteristics of traditional Chinese medical constitution of patients with type 2 diabetes mellitus （T2DM）, and to explore the relationship of Chinese medical constitution types with the related risk factors. Methods A questionnaire survey was conducted in 147 patients with type 2 diabetes mellitus, and the characteristics of their constitution as well as the relationship of constitution types with risk factors of insulin resistance index （IRI） and insulin sensitivity index （ISI）was analyzed. Results Yin-deficieney constitution （24.49%） was the main constitution types of T2DM, and then came blood-stasis constitution （14.29%）, Qi-deficiency constitution （12.93%）, phlegm-damp constitution （12.24%）, normal constitution （8.84%）, yang-deficiency constitution （6.80%）, damp-heat constitution （ 10.20% ）, Qi-depression constitution （6.12%）, and special constitution （4.08%） . Yin-defieieney constitution showed significant difference with the other types of constitution （P 〈0.01） . Phlegm-damp constitution had the highest IRI and the lowest ISI （P 〈 0.01） . Yin-deficiency constitution had the lowest function levels of islet beta cell （P〈0.05 or P〈0.01） . All of the constitution types were correlated with diabetic risk factors such as smoking, alcohol consumption, body mass index （BMI）, waist to hip ratio （WHR）, fasting plasma glucose （FPG）, fasting C-peptide , fasting insulin （FINS）, HbAlc, lipids, and inflammatory factors to various degrees （P〈0.05 or P〈0.01 ）. Conclusion The constitution types of T2DM patients are correlated with IRI and ISI.
出处
《广州中医药大学学报》
CAS
北大核心
2013年第3期312-315,319,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
2型糖尿病
中医体质
胰岛素抵抗指数
胰岛素敏感指数
Type 2 diabetes mellitus
Traditional Chinese medical constitution
Insulin resistance index
Insulin sensitivity index
