摘要
目的探讨脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)与抑郁症及其执行功能的关系。方法随机抽取68例抑郁症患者及71例正常人为研究对象,采用ELASA法检测血清BDNF水平、PCR-RFLP技术检测BDNF rs6265多态位点基因多态性,应用威斯康星卡片分类测验(Wisconsin Card Sor-ting Test,WCST)评估执行功能。结果抑郁症组与WCST有关的执行功能明显差于对照组(t=2.02～4.82,P均<0.05);抑郁症组血清BDNF水平低于对照组(t=3.62,P<0.001),其蛋氨酸携带率(89.7%)高于对照组(79.4%)(P<0.05);抑郁症血清BDNF水平与分类数明显相关(r=0.27,P<0.05),携带蛋氨酸组非持续错误数低于非携带蛋氨酸组(z=0.20,P<0.05)。结论血清BDNF水平及其rs6265多态位点基因多态性与抑郁症的执行功能有关。
Objective The current study focused on the association of brain-derived neurotrophic factor （BD- NF） with depression and executive function. Methods The study was performed in 68 depressive disorders and 71 healthy controls. They were all investigated by the Wisconsin Card Sorting Test （WCST）to evaluate executive function. We measured the serum BDNF level by ELISA and the rs6265 polymorphism by PCR-RFLP. Results Compared with the control group, depressed patients had poorer executive function （t = 2.02 ~ 4.82, P^0.05） and lower serum BDNF levels （t ~ 3.62, P^0. 001）. The frequency of BDNFrs6265 Met allele gene in depressive disorders（89.7 % ）was significantly higher than that in negative controls （79.4 % ）. The serum BDNF levels was significantly correlated with number of categories. The depressive disorders with BDNFrs6265 Met allele gene had significantly lower non persist error number than that in BDNFrs6265 non Met allele. Conclusion The serum BD- NF levels and the BDNFrs6265 polymorphism may correlate with depression and executive function,
出处
《济宁医学院学报》
2013年第2期80-83,共4页
Journal of Jining Medical University
基金
山东省自然科学基金(编号:ZR2010CM031)
