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急性心肌梗死患者双联抗血小板治疗加用质子泵抑制剂对预后的影响 被引量：11

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摘要 目的:探讨急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)治疗后,对有消化道出血风险的高危患者,在双联抗血小板治疗基础上分别加用奥美拉唑、泮托拉唑对心血管事件的影响。方法:随机选取2009年1月至2012年1月住院的AMI患者179例,在双重抗血小板治疗基础上,依据有无消化道出血高危因素,随机分为:安慰剂治疗组、加用泮托拉唑组及加用奥美拉唑治疗组,随访3组12个月内心血管事件及消化道出血事件,比较3组12个月冠状动脉血管内径丢失情况。结果:随访12个月,3组心血管事件、消化道出血事件及冠脉管腔丢失差异均无统计学意义(P>0.05)。结论:对有消化道出血高危风险的AMI患者,在冠状动脉支架植入术后双重抗血小板治疗过程中,加用奥美拉唑或泮托拉唑预防消化道出血,不增加心血管事件,对冠状动脉支架植入术后再狭窄无影响,两种质子泵抑制剂之间亦无差异。
作者 郑若龙 陈新军 钱惠东 李伟章 蒋文龙 魏峰 徐卓文 张华
机构地区 东南大学医学院附属江阴医院心内科
出处 《实用医学杂志》 CAS 北大核心 2013年第9期1465-1467,共3页 The Journal of Practical Medicine
基金 无锡市科技局社科项目(编号:CSZOON1131)
关键词 心肌梗死 双重抗血小板治疗 质子泵抑制剂
分类号 R542.22 [医药卫生—心血管疾病]
  • 相关文献

参考文献8

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共引文献443

同被引文献89

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引证文献11

二级引证文献64

实用医学杂志
2013年 第9期

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