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支气管哮喘患者sVCAM-1和ECP的分析 被引量:1

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摘要 本文对支气管哮喘患者和健康人采用双抗体夹心法ELISA测定sVCAM 1,用荧光免疫法测定血清ECP、血清总IgE(tIgE )和特异性IgE (sIgE )。结果显示 ,哮喘组的血清sVCAM 1显著高于对照组 ;两组血清ECP含量未见明显差异 ,但哮喘急性发作期的血清ECP水平明显高于缓解期患者 ;哮喘组血清总IgE几何均数显著高于对照组 ;血清sIgE分析提示蒿草花粉 (83 % )和户尘螨 (5 2 % )的sIgE不仅阳性检出率高 ,而且其血清sIgE的含量亦较高。多因素分析提示 :血清sVCAM 1与tIgE (r=0 5 0 3,P =0 0 14)、tIgE与sIgE (r=0 837,P =0 0 0 0 1)、ECP与哮喘疾病状态 (r=0 772 ,P =0 0 0 0 1)呈正相关关系。由此可见 ,支气管哮喘患者的血清sVCAM 1较正常人高 ,并且与血清tIgE的升高有关 ;血清sIgE增高会导致血清tIgE增高 ;血清ECP的含量增高与哮喘发作有关。
出处 《上海免疫学杂志》 CSCD 北大核心 2000年第5期311-312,共2页 Shanghai Journal of Immunology
基金 卫生部科研基金!资助项目 (96 1 312 )
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同被引文献9

  • 1曹国强,崔社怀,吴奎,林海龙,毕玉田,杨肇亨.哮喘患者血清可溶性E选择素、血管细胞黏附分子1浓度的变化[J].中国现代医学杂志,2004,14(22):52-54. 被引量:5
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  • 6Khayyamian Saman,Huttoff Andreas,Buchner Kerstm,et al.ICOS-ligand,expressed on human endothelial cells,costimulates Th1 and Th2 cytokine secretion by memory CD4+T cells[J].Proceedings of the National Academy of Sciences of the United States of America,2002,99:6198-6203
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  • 8康庆德,魏庆云,谢秀兰,吴丽萍,张卓,付艳华,季光协,马全海,宋子云,王德冲.黑龙江人体寄生虫分布调查结果的分析[J].中国寄生虫学与寄生虫病杂志,1994,12(S1):71-74. 被引量:10
  • 9卢玉莲,崔徵,蒋丽,郝淑维.可溶性粘附分子与妊娠高血压综合征[J].国外医学(妇产科学分册),2002,29(1):21-23. 被引量:14

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