摘要
目的:探讨二甲双胍配伍吡格列酮治疗2型糖尿病临床效果及其安全性。方法:将我院100例2型糖尿病患者随机分为观察组和对照组各50例,观察组采用二甲双胍配伍吡格列酮治疗方案,对照组单独使用二甲双胍治疗,共治疗16周。观察两组治疗前后空腹、餐后2h血糖及胰岛素敏感性、不良反应等指标,对比两组临床疗效,分析二甲双胍配伍吡格列酮治疗2型糖尿病的安全性。结果:观察组有效率为96.0%,对照组有效率为76.0%,两组疗效对比,观察组明显优于对照组,差异具有显著性(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:吡格列酮联合二甲双胍治疗2型糖尿病,能有效地控制FPG、餐后2h血糖水平,增强胰岛素的敏感性,有效改善胰岛素抵抗,此作用优于单一使用二甲双胍,且安全性良好。
Objective： To explore the combination of metformin pioglitazone treatment in type 2 diabetes： clinical efficacy and safety. Methods： 100 cases of＇patients with type 2 diabetes were randomly divided into the observation group and the control group with 50 cases in each group, the observation group was treated with pioglitazone metformin treatment regimens, controls individually using mctformin treatment, a total of 16 weeks treatment. Treatment in the two groups were observed before and after fasting, postprandial glucose and insulin sensitivity in2h, adverse reactions and other indexes, comparing the two groups of clinical curative effect analysis of mctformin, pioglitazone treatment in type 2diabetes mellitus with safety. Results： The observation group efficiency is 96%, the effetcive rate of control group was76%, between tbe two groups, the observation group was better than the control group, the difference was signilieant （ P〈0.05）： the incidence of adverse reactions compared two groups, the difference was not statistically signilicant （P〉0.05）. Conclusion： Combined pioglitazone and metformin in treating type 2 diabetes mellitus, can effectively control FPG,2h postprandial plasma glucose, enhanced insulin sensitivity, improve insulin resistance, the effect is better than the single use of metformin, and the security is good.
出处
《中国医药导刊》
2013年第3期473-474,共2页
Chinese Journal of Medicinal Guide
关键词
吡格列酮
二甲双胍
2型糖尿病
Pioglitazone
Metformin
Type 2diabetes mellitus
