摘要
红细胞膜上具有免疫粘附作用的C_(3b)受体,它能够吸附并清除血液循环中的免疫复合物。本文应用简易的红细胞C_(3b)受体花环试验与红细胞免疫复合物花环试验方法,对30例血液病患者的红细胞免疫功能进行了测定。结果表明,白血病患者,再障患者及自免贫患者C_(3b)受体花环率均明显降低,白血病患者免疫复合物花环率相对较高。本文对血液病患者红细胞免疫功能变化的机理及影响因素进行了初步探讨,提示红细胞免疫功能的测定可做为血液病患者治疗,预后的一个观察指标。
Red cells possess immune eapabilities throngh C_(sb) receptors on its surface. Therefore, red cells can adhere to Ag-Ab complement complexes and clear them away from circulation. Red cell immune functions were detected in 30 cases of blood diseases. The results show that there is remarkable decrease in the rosette rate of red cell C_(3b) receptors in patients of leukemia, aplastic anemia and autoimmune hemolytic anemia, and relative increase in that of immune complex in patients of leukemia. The mechanisms and effectors of these changes were studied. It suggests that the detection of red cell immune functions could be as reference data for the treatment and prognosis of blood diseases.
关键词
血液病
红细胞
免疫功能
blood diseases
red cell
receptor
immune
rosette test
