摘要
目的探讨ASPP蛋白(包括ASPP1,ASPP2,IASPP)在胃癌发生发展中的作用以及胃癌、胃腺瘤性息肉的相互关系。方法应用免疫组化法分别检测慢性胃炎、胃腺瘤性息肉和胃腺癌中ASPP1,ASPP2,IASPP的表达。结果 ASPP1,ASPP2,IASPP的阳性表达率分别为:胃癌(22.5%,27.5%,67.5%)、腺瘤性胃息肉(48.0%,52%,40.0%)、慢性胃炎(72.5%,80.0%,17.5%),在胃癌中的阳性表达与其他两组比较,差异有显著性(P均<0.05);上述3种因子在腺瘤性胃息肉与慢性胃炎之间差异显著(P均<0.05)。结论检测胃息肉和胃癌中ASPP1,ASPP2及IASPP蛋白的表达,有助于推测胃息肉的生物学行为发展趋势,早期诊断胃癌并判断其预后。
Objective To investigate the roles of ASPP protein in pathogenesis of adenomatous polyps and gastric carcinoma. Methods lnummohistoehemistry was used to detect ASPP protein in 105 specimens of stomach,including chronic superficial gastritis,adeno- matous polyp and carcinoma. Results In the chronic superficial gastritis,adenomatous polyp and carcinoma,the expression rate of ASPP1, ASPP2 ,IASPP were 72.5%/80.0%/17.5% ,48.0%/52%/40.0% ,22.5%/27.5%/67.5% respectively. The positive rate of ASPP1 ,AS- PP2 and IASPP were all significantly different from gastric cancer and the other tissues,and the positive rate of ASPP1 ,ASPP2 and IASPP of the chronic superficial gastritis and adenomatous polyp were different either. Conclusion Detection of ASPP protein is very helpful to deter- mine the development and biological behavior of gastric polyp,early diagnosis and prognosis of carcinoma.
出处
《潍坊医学院学报》
2013年第2期150-151,I0002,共3页
Acta Academiae Medicinae Weifang
