摘要
目的探讨超声引导下单极冷循环射频消融（RFA）治疗毗邻胸壁周围型肺癌的疗效及安全性。方法对35倒周围型肺癌患者的35个肿瘤行超声引导下RFA治疗。治疗后l～3个月行增强CT（CECT）扫描，评价治疗疗效，如肿瘤灭活不全或复发行追加治疗；治疗后6～12个月复查CECT评估中远期疗效。结果35例患者RFA治疗顺利，治疗后第l～3个月CECT复查，肿瘤无强化为68．6％（24／35），肿瘤部分强化为31．4％（11／35），对肿瘤部分强化者行再次RFA治疗。治疗后6-12个月CECT复查，肿瘤无强化71．4％（25／35），肿瘤增大并部分强化28．6％（10／35）。RFA治疗10d后血清CYFRA21-l水平与治疗前比较差异无统计学意义（P〉0．05）；治疗后20d及30d分别与治疗前比较CYFI／A21-l水平明显下降，差异有统计学意义（P〈0．05）。结论超声引导单极冷循环RFA治疗毗邻胸壁的周围型肺癌，能实时观察进针方向，操作方便，穿刺成功率高，并发症少，费用较低，是一种安全、可行、有效的治疗方法、
Objective To evaluate the efficacy anti safety of treating the peripheral lung cancer by uhrasound-guided unipolar cool-tip radiofrequency ablation（ RFA ）. Methods Thirty-five masses of 35 peripheral lung caneer cases were treated by ultrasound-guided RFA. 1 -3 monlhs after heing treated,these cases undergone RFA were examined by CECT to evaluate the efficacy. If insufficiency inactiva- tion or palindromia,these cases would be treated by RFA again and examined with C ECT 6 - 12 months later to evaluate the hmg term effica- cy. Results Thirty-five cases were treated by RFA successfully. 1 - 3 months after RFA treatment,68.6% （24/35） masses showed no en- ham＇ement and 31.4% （11/35） showed partial enhancement. These cases showing partial enhancement were treated by RFA again. 6 - 12 monlhs after RFA,the CECT results showed no enhancement in 71.4% （25/35） cases and enlargement and partial enhancementin in 28.6% （ 10/35 ） cases. There was no significant difference in serum CYFRA21-1 level between 10 days ＇after RFA and before RFA （ P 〉0.05 ）. But 20 or 30 days after RFA treatment,the serum CYFRA21-1 level wax significantly lower than before RFA（P 〈 0.05）. There was no serious complications after RFA treatment except 4 cases with mild pneumothorax,2 cases with moderate or marked pnemnothorax tread by thoracic closed drainage and 1 case with subcutaneous emphysema. Conclusion Ultrasound guided cool-tip RFA can make needliug direction be real- timely observed and it is convenient,with high puncture success rate,less complications and low cost. It is a safe,feasible amt effective meth- od of treating the peripheral lung cancer.
出处
《潍坊医学院学报》
2013年第2期94-96,I0001,共4页
Acta Academiae Medicinae Weifang
关键词
超声检查
单极冷循环
肺肿瘤
射频消融术
增强CT
[lltrasomld examination
Unipolar coht circulation
Pulmonary tumor
Radiofrequency ablation
Enhanced CT
