摘要
目的探讨血必净对重度烧伤患者早期重要脏器功能的作用,并观察其对早期炎性反应的相关炎性因子C-反应蛋白(CRP)、前降钙素(PCT)水平的影响。方法将40例重度烧伤患者随机分为实验组和对照组,每组20例,对照组按常规补液、创面处理、合理应用抗生素等治疗,实验组在常规治疗的基础上静脉滴注血必净注射液100mL,2次/d,7d一个疗程。测定两组用药前、用药后第3天、用药后第7天静脉血谷丙转氨酶(ALT)、谷草转氨酶(AST)、肌酸激酶(CK)、尿素氮(BUN)、肌酐(Cr)、CRP及PCT浓度。结果患者用药前提取血清标本,测定CRP、PCT浓度,两组比较差异无统计学意义(P>0.05);测定血ALT、AST、CK、BUN、Cr浓度,两组比较差异无统计学意义(P>0.05)。实验组应用血必净第7天血CRP(32.76±5.0)、PCT(1.4±0.3)浓度较第3天CRP(46.52±15.00)、PCT(3.1±0.3)明显下降,与对照组比较差异有统计学意义(P<0.05);实验组应用血必净第7天ALT(45.1±8.0)、AST(37.9±7.3)、CK(150.9±25.2)、BUN(5.1±1.3)、Cr(41.5±8.2)明显下降,与对照组比较差异有统计学意义(P<0.05)。结论血必净能减轻由细胞炎性因子介导的炎性反应,有效保护重度烧伤患者早期各脏器功能。
Objective To explore the effects of Xuebijing on major organ functions at the early stage of severe bum and its effects on the levels of C reactive protein （CRP） and procalcitonin （PCT）. Methods Forty severe bum patients were randomly divided into the treatment group （ n = 20） and the control group （n = 20）. Patients in the control group received the primary treatment included immediate and optimal fluid resuscitation supporting the systematic defense power and dealing with the wounds correctly. Antibiotics were employed reasonably. While those in the treatment group received intravenous dripping of Xuebijing on the basis of routine therapy. Blood samples were taken for the determination of serum alanine transaminase （ ALT）, aspartate transaminase （ AST）, creatine kinase （ CK）, blood urea nitrogen （ BUN ） , creatinine （Cr）, CRP and PCT. Results The serum ALT, AST, CK, BUN, Cr, CRP and PCT levels of admission patients of the treatment group and control group were detected before treatment, which showed no significant differences between the two groups （P 〉0.05）. Three days after treatment, CRP was 46.52 ± 15.00, PCT 3.1 ±0.3 and 7 days CRP 32.76 ±5.0, PCT 1.4 ±0.3. The serum ALT, AST, CK, BUN, Cr, CRP and PCT levels of the treatment group were significantly decreased more than those of the control group. There was obvious difference between the two groups （ P 〈 0.05 ）. Conclusions Xuebijing can decrease the injury severity of inflammatory reaction by cytokines and obviously protect functions of major organs in patients with severe burn injury at the early stage.
出处
《中华损伤与修复杂志（电子版）》
CAS
2013年第1期45-48,共4页
Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)
基金
2009年度青海大学中青年科研基金(2009-QY-23)
关键词
烧伤
血必净
C反应蛋白
前降钙素
Burns
Xuebijing
C reactive protein
Procalcitonin
