摘要
目的 比较双氯芬酸钠及双氯芬酸赖氨酸体内药代动力学参数。方法 2 0只Wister大鼠分成二组分别单次灌胃给予1.0mmol·L- 1 1.4ml双氯芬酸钠 (DS)和双氯芬酸赖氨酸 (DL) ,用高效液相色谱法测定血中DS及DL浓度。用 3P87程序拟合计算药代动力学参数。结果与结论 经统计学方差分析 ,药 时曲线符合二室模型 ,两种双氯芬酸盐的AUC ,Vd ,tmax,cmax,CL无差异 (P >0 .0 5 ) ,两组t1 2 β有显著差异 (P <0 .0 1)
OBJECTIVE To compare the pharmacokinetic parameters between diclofenac sodium and diclofenac lysine.METHODS 20 wister rats were divided into two groups randomizedly by oral administration of diclofenac sodium and diclofenac lysine,respectively and the same concentration of 1.0 mmol·L -1 and the same quantity of 1.4 ml.The blood sample were collected through rats neck vein with intubation.A HPLC method was used to determine the concentrations of diclofenac in plasma.RESULTS The plasma concentration time curves were fitted to two compartment model.CONCLUSION The pharmacokinetic parameters between the two products had no significant difference ( P >0.05),except t 1/2β ( P <0.01).
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2000年第7期467-469,共3页
Chinese Pharmaceutical Journal
