摘要
目的：研究地塞米松对严重哮喘合并呼吸道合胞病毒患者气道及其炎症的效果。方法：120例呼吸道合胞病毒感染者，65例1年内均发生多次哮喘，本次入院为急性哮喘重度发作。将合胞病毒感染患者分为抑制剂组（A组30例），兴奋剂组（B组35例）；单纯感染分为抑制剂组（c组25例），兴奋剂（D组30例）。所有患者均进行积极抗病毒治疗，A、c组前2周醋酸地塞米松注射液肌肉注射，每日8-16mg，而后行静脉点滴注射，每日8mg，2周；B、D组每日雾化吸人利多卡因100mg，连续治疗1个月。对比A、B两组，C、D两组患者的IL－4、IL－5、IL-13、IFN－y的水平及气道反应性FEV1、PEF水平，比较c、D两组哮喘的发病率。结果：无创肺功能监测显示，A、C两组的气道顺应性高于B、D组；A、c组炎性介质水平低于B、D组；此外D组患者中3例并发哮喘，两组治疗期间未见明显不良反应。结论：地塞米松对于重度哮喘合并呼吸道合胞病毒疗效明确，可以降低气道高反应性，降低气道炎症反应，此外具有一定的预防哮喘发生的作用。
Objective： To study the effect of severe asthma patients with respiratory syncytial virus merger airway inflammation with dexamethasone. Methods： 120 patients with respiratory syncytial virus infections, 65 cases a year happened many times are asthma, the admission for acute severe asthma attacks.Will syncytial virus infection patients into inhibitor group （A group=30）, doping （B group=35）.Simple infection divided into inhibitor C group（n=25）, doping D group（n=30）.All patients were positive antiviral treatment, including A, C group dexamethasone acetate injection two weeks before the intramuscular injection（daily 8-16 nag）, and then do intravenous fluid infusion daily and 8 mg for 2 weeks; B, D group daily atomization inhalation lidocaine 100 rag, continuous 1 months of therapy.Contrast A, B two groups, C, D two sets of patients IL-4, IL-5, IL-13, IFN ppar-gamma level and airway reactivity FEV1, PEF level. And C, D two groups the incidence of asthma.Results： Non lung function monitoring display A, C two groups of airway compliance with higher than B, D group; A, C inflammatory medium level lower than B, D group; In addition there are three cases in D group with asthma, two groups during treatment did not see obvious adverse reactlon.Conclusion： Dexamethasone for severe asthma combined respiratory syncytial virus curative effect definite, can reduce airway high reactivity, lower airway inflammation, in addition has a certain role to prevent asthma.
出处
《中外医学研究》
2013年第13期7-8,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
地塞米松
哮喘
呼吸道合胞病毒
Dexamethasone
Asthma
Respiratory syncytial virus
