摘要
目的：建立感清颗粒的制备工艺。方法：以没食子酸、石吊兰素为评价指标，采用L9（3^4）正交试验法优选感清颗粒的提取工艺，以颗粒吸湿性、流动性和成型性为指标对干法制粒的工艺进行研究。结果：最佳提取工艺为加7倍水，回流提取2次，每次1h，75℃～80℃减压浓缩至相对密度1．09，干法制粒制备得到的颗粒吸湿性、流动性和成型性好。结论：优选得到的感清颗粒工艺稳定可行，可应用于工业化生产。
This study was aimed to optimize the preparation process of Ganqing Granules. The optimal extraction of Ganqing Granules was investigated by the L9（3^4） orthogonal experiment. With gallic, nevadensin, hygroscopicity, fluidity and formability as the indexes, the dry granulating process was evaluated. The results showed that the optimal extraction procedures were as follows： adding 7-fold water, refluxing extraction for 2 times （1 hour per time）; concentrating of reduced pressure to the relative density of around 1.09 under the temperature of 75~C- 80~C; the hygroscopicity, fluidity and formability of granules were in accord with manufacture requirements. It was concluded that the optimized formation processes of Ganqing Granules are stable and feasible, which can be used for the industrialized production.
出处
《世界科学技术-中医药现代化》
北大核心
2013年第2期310-316,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
贵州省中药现代化科技产业研究开发专项(黔科合中药[2010]5006号):贵州苗药感清糖浆的二次开发研究(临床前)
负责人:田源红
关键词
感清颗粒
综合评价
制备工艺
Ganqing Granules, comprehensive assessment, preparation technology
