摘要
目的 :探讨血清可溶性白细胞介素 2受体 (sIL 2R)在急性中毒中的临床意义。方法 :采用ELISA法检测 80例急性中毒患者 (镇静催眠药、乙醇、一氧化碳及农业杀虫剂各 2 0例 )及 2 0例正常人血清sIL 2R。结果 :急性乙醇中毒组 (AL组 )与急性一氧化碳中毒组 (CO组 )血清sIL 2R均高于正常对照组 (P <0 0 5 ) ,急性镇静催眠药中毒组 (SH组 )、急性农业杀虫剂中毒组 (FI组 )与对照组比较差异无显著性 (P >0 0 5 ) ;各中毒组间差异无显著性 (P >0 0 5 )。AL组治疗后sIL 2R低于治疗前 (P <0 0 5 ) ,CO组治疗后sIL 2R明显低于治疗前 (P <0 0 1) ,SH组与FI组治疗后sIL 2R与治疗前差异无显著性 (P >0 0 5 )。结论 :急性乙醇中毒与急性一氧化碳中毒均可致sIL 2R增高 ,经用糖皮质激素治疗后sIL 2R降低较非糖皮质激素治疗更明显 ,故糖皮质激素治疗有免疫异常的急性中毒尤其是无特效解毒剂治疗的急性中毒是切实可行而有效的。
Objective:To investigate the relationship between serum soluble interleukin 2 receptor(sIL2R) levels and acute poisoning.Methods:Serum sIL2R levels in 80 acute poisoning subjects and 20 normal control subjects were measured with enzyme linked immunosorbent assay(ELISA).80 subjects with acute poisoning were divided into 4 groups equally:acute sedative hypnotic poisoning(SH),acute alcohol poisoning(AL),acute carbon monoxide poisoning(CO),and acute farm insectiside poisoning(FI).Results:The levels of serum sIL2R in AL and CO were significantly higher than those in controls(P<005).No significant differences were shown between SH,FI and controls(P>005).The levels of sIL-2R were markedly decreased in AL and CO after treatment(P<005 and P<001 respectively).There were no significant differences in SH,FI before and after treatment(P>005).Conclusion:The significant elevation of serum sIL2R levels were shown in AL and CO.The levels of sIL2R decreased after treatment with glucocorticoid much more markedly than those treated with non-glucocorticoid.So the treatment with glucocorticoid is feasible and effective for acute poisoning associated with immunologic disturbance especially for those wihtout any specific antidote.
出处
《急诊医学》
CSCD
2000年第4期225-226,287,共3页
