摘要
目的 研究在急性心衰状态下动力性主动脉成形术对血液动力学的影响。方法 8条杂种犬 ,游离背阔肌 ,游离胸降主动脉 ;以背阔肌瓣包绕降主动脉 ;以异搏定诱导心衰 ;以骨骼肌刺激器刺激背阔肌瓣收缩。结果 心衰诱导满意 ,在主动脉成形术 (反搏 )后 ,与心衰时相比 ,舒张期平均压上升了 18 5 % ,心内膜下活力指数上升了 17 0 % ,冠脉流量增高了 2 6 8% ,肺毛细血管楔压下降了 19 4%。结论 在急性实验中 ,动力性降主动脉成形术可改善冠脉灌注和心肌氧供 ,改善心功能。该术式为充血性心衰病人提供了一种新的治疗途径。
Objective: To determine the role of dynamic descending aortomyoplasty to assist circulation after induction of acute heart failure. Method: Eight dogs were used. General anesthesia was induced and maintained with thiopental sodium. The experimental procedures(1) Preparation of latissimus dorsi muscle, a bipolar electrode was placed adjacent to the neurovascular bundle. (2) Dissection of the aorta. (3) Wrapping the latissimus dorsi muscle around the aorta. (4) Heart failure was induced by the administration of Isoptin. (5) Electrostimulate the latissimus dorsi muscle during diastole. Result: Induction of heart failure was satisfactory. Upon electrostimulation, significant improvement in average diastolic pressure(+18.5%), endocardial viability ratios(+17%), and coronary flow(26.8%) were deserved, pulmonary capillary wedge pressure (19.4%) was decreased significantly. No significant change was found in systemic vascular resistance. Conclusion: In acute experiment, the dynamic descending aortomyoplasty improves the coronary flow and cardiac function after induction of heart failure, and may therefor be useful for treating coronary artery disease and congestive heart failure.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2000年第4期228-230,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
