摘要
目的探讨骨髓铁染色、血清铁蛋白检测结果的相关性在贫血性疾病诊断及预后的临床价值。方法 207例贫血性疾病患者,用雅培i2000化学发光仪测定血清铁蛋白,普鲁兰反应试剂检测骨髓铁,其中排除肝病、发热及铁剂治疗的患者84例(第1组);白血病组55例(第2组);恶性疾病、感染、发热、肝病及铁剂治疗组68例(第3组);正常对照组:男性141例,女性171例。结果单纯缺铁性贫血患者的骨髓铁染色与血清铁蛋白含量明显低于正常参数值;第1组的患者:骨髓铁染色和血清铁蛋白呈良好的正相关(n=84,γ=0.475,P<0.01);白血病患者(第2组)的骨髓铁染色与血清铁蛋白含量之间也呈显著正相关(n=46,γ=0.620,P<0.01);慢性白血病患者血清铁蛋白含量的增高和变化不如急性白血病明显;第3组骨髓铁染色与血清铁蛋白含量之间无相关关系(n=68,γ=0.168,P>0.05)。结论在排除肝病、发热及铁剂治疗的情况下,患者血清铁蛋白含量可反映机体贮存铁的水平,此时可不需要骨髓穿刺,可以用测定血清铁蛋白含量来了解机体铁储存情况。白血病患者血清铁蛋白含量变化幅度显著高于骨髓铁染色,发病时显著增高,完全缓解时可降至正常或近乎正常,当复发或病情恶化时又升高,骨髓铁染色变化幅度不大。因此可以通过观察血清铁蛋白动态变化,来判断病情是否缓解或复发或病情恶化,以评估疗效。
Objective To discuss the relationship between the test results by using of bone marrow iron stain and serum ferritin in a- nemic disease diagnosis clinical value. Methods There were 207 cases of patients with anemia. We used Abbott i2000 chemilumines- cence apparatus to detect their serum ferritin and used Pullulan reaction reagent to detect their bone marrow iron stain. We eliminated 78 cases of patients with hepatopathy, fever and iron therapy （ 1 group）, and Selected 55 cases of patients with leukemia （2 group） ,68 cases of patients with malignant, infection, fever, hepatopathy and iron therapy （3 group） , and normal control 141 male patients and 171 fe- male patients. Results The bone marrow iron stain and the content of serum iron protein of the pure iron deficiency anemia were lower than the normal parameter value obviously. For the patients in the 1 group, bone marrow iron stain and serum ferritin had perfect positive correlation （ n = 84 ,γ= 0.475 ,P 〈 0.01 ）. The bone marrow iron stain and serum ferritin of leukemia patients （ the 2 group） had promi- nent positive correlation as well （ n = 46,γ = 0. 620,P 〈 0.01 ）. The increase and variation of the content of serum iron protein of chronic leukemia patients was much lesser than that of patients with acute leukemia. In 3 group, bone marrow iron stain had no relationship with the content of serum ferritin （n = 68 ,γ = 0. 168, P 〉 0.05 ）. Conclusion In the exclusion of hepatopathy, fever and Iron agent treat- ment, the content of serum iron protein can reflect the body storage level of iron. Under this circumstance, we can know the body storage level of iron without bone marrow aspiration to detect the content of serum iron protein. The content of serum iron protein of leukemia pa- tients is higher than bone marrow iron stain and is significantly higher when attacking. The content of serum iron protein can reduce to nor- mal when disease is in remission but increase when in relapse or in exacerbation. The change range of bone marrow iron stain is not huge. We can determine illness alleviating or recurrence or exacerbation by watching dynamic change serum ferritin, to evaluate the clinical effects.
出处
《医学研究杂志》
2013年第4期166-170,共5页
Journal of Medical Research
关键词
贫血
血清铁蛋白
骨髓铁染色
相关性研究
Anemia
Serum ferritin
Bone marrow iron stain
Correlation research
