摘要
目的:探讨八聚体结合蛋白4(Oct4)在食管鳞癌组织中的表达及其与食管癌患者预后的关系。方法:免疫组织化学SP法检测58例食管鳞癌及21例癌旁正常黏膜组织中Oct4蛋白的表达,分析其与各临床病理指标的关系;并结合Oct4表达情况及患者最短为期8年的随访资料,Kaplan-Meier法和Log-Rank检验分析Oct4与食管癌患者生存的关系;Cox回归模型评估Oct4及各病理指标与患者预后的关系。结果:食管鳞癌组织中Oct4阳性表达率为60.3%(35/58),显著高于正常组织中的19.0%(4/21),χ2=10.519,P=0.001;Oct 4的表达与患者年龄(χ2=0.023,P=0.879)、性别(χ2=0.043,P=0.836)、淋巴结转移(χ2=0.551,P=0.458)、外膜浸润(χ2=0.364,P=0.546)及UICC分期(χ2=1.038,P=0.308)均无相关性,但与组织学分级明显相关,χ2=6.061,P=0.014。死亡患者的Oct4表达程度也明显高于生存患者,χ2=7.958,P=0.005;且Oct4阳性表达患者的生存时间明显短于阴性表达的患者,χ2=7.703,P=0.006。Oct4表达水平与食管癌患者预后明显相关,RR=2.243,P=0.001。结论:Oct4在食管鳞癌组织中的表达水平与组织学分级及患者生存期相关,Oct4是影响食管癌患者预后的独立因素。
OBJECTIVE： To study the expression of Oct4 in esophageal squamous cell carcinoma （ESCC） and ana- lyze the relationship between the expression of Oct4 and clinical prognosis. METHODS： Immunohistochemistry staining SP was used to detect the expression level of Oct4 in 58 cases of ESCC and 21 normal mucous memebrane. Subsequently the relationship between postoperative pathological features with the expression of Oct4 was analyzed. These 58 patients were followed for 8 years at least. Kaplan-Meier method and Log-Rank test were employed to explore the correlation be tween Oct4 expression and survival, and Cox regression analysis was performed to evaluate the connection between expres- sion of Oct4 and prognosis. RESULTS： The positive expression rate of Oct4 in ESCC was 60.3 % （35/58）,obviously high- er than that of normal esophageal （19.0%,4/21X^2 =10. 519,P：0. 001）. There was no significant difference in the ex- pression of Oct4 among patients with age （X^2 =0. 023,P=0. 879） ,gender （Xz =0. 043 ,P=0. 836） ,lymph mode metasta- sis （X2 =0. 551,P=0. 458） ,invasion of adventitia （X^2=0. 364,P=0. 546） and UICC stage （X^2=1. 038,P=0. 308）. The expression of Oct4 in low differentiation group was higher than that in well or moderate differentiated（X^2 = 6. 061, P= 0. 014）. Oct4 expression was higher in deaths than that in survival cases （X^2 =7. 958,P=0. 005）. Patients with higher expression of Oct4 had significantly shorter survival time （Xz = 7. 703,P= 0. 006）. The expression of Oct4 was obviousIy correlated with the prognosis of ESCC （RR= 2. 243,P： 0. 001）. CONCLUSION： The expression of Oct4 is related to the differentiation and survival time of patients with ESCC,and it is an independent prognostic factor for ESCC.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2013年第10期753-756,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
河北省教育厅自然科学指导项目(Z2011207)
关键词
OCT4
食管鳞状细胞癌
预后
生存期
Oct4
Esophageal squamous cell carcinoma ~ Prognosis
Survival time
