摘要
目的:测定子宫肌瘤、卵巢囊肿患者血清及病理组织中酞酸酯类化学物(PAEs)水平并分析其相关性。方法:收集80例子宫肌瘤和67例卵巢囊肿患者的手术病理组织和血液样本,采用气相色谱法(GC)测定PAEs含量。并对病理组织与血清中邻苯二甲酸二丁酯(DBP)和邻苯二甲酸二(2-乙基-己基)酯(DEHP)水平进行相关性分析。结果:患者病理组织中DEP、DBP和DEHP的检出率分别为0、74.8%和99.3%。卵巢囊肿病理组织中DBP和DEHP水平分别为0.457μg/g和4.123μg/g,均显著高于子宫肌瘤组织(0.202μg/g、2.317μg/g,P<0.001)。子宫肌瘤患者血清中DEHP与病理组织中DBP和DEHP的水平均呈负相关(r=-0.241,P<0.05;r=-0.309,P<0.01);卵巢囊肿患者血清中DBP与病理组织中DBP含量呈负相关(r=-0.255,P<0.05);卵巢囊肿患者的黄体生成素水平显著低于子宫肌瘤患者(3.80IU/L vs 8.72IU/L,P<0.05)。结论:PAEs对女性人群暴露与子宫肌瘤、卵巢囊肿发病的相关性研究有一定的参考意义。
Objective：To detect the phthalate acid esters （PAEs） level of pathological tissue in uterine fibroids and ovarian cysts patients and analyze its correlation. Methods：To col- lect the pathological tissue and blood sample from 147 cases of uterine fibroids and ovarian cysts patients and determine the PAEs level via gas chromatography （GC）. Spearman correlation was used for statistical analysis. Result：The positive ratios of DEP, DBP and DEHP in 147 cases were 0,74.8% and 99. 3% respectively. The levels of DBP and DEHP in ovarian cysts tissue were 0.457μg/g and 4. 123 μg/g, which were significantly higher than those in uterine fibroids （0.2021μg/g, 2. 317 μg/g, P〈0. 001 ）. The DEHP level in the ,blood serum of uterine fibroid patients was negatively correlated to the DBP and DEHP levels in pathological tissue （r = -0.241,-0.309 respectively ;P〈0.05, P〈0.01 respectively）. The DBP level in the blood serum of ovarian cysts patients were negatively correlated to the DBP level in pathological tissue （ r = -0.255, P〈0.05 ）. Lutejnizing hormone level of ovarian cysts patients was significantly lower than that of uterine fibroid patients （ 3.80 IU/L vs 8.72 IU/L, P〈0.05 ）. Conclusion： The correlation research between women＇s exposure to PAEs and the incidence of uterine fibroids and ovarian cysts is referentially significant.
出处
《现代妇产科进展》
CSCD
2013年第4期297-301,共5页
Progress in Obstetrics and Gynecology
基金
国家自然科学基金资助项目(No:81172673)
上海市卫生局资助课题(No:2010257)
