摘要
目的观察神经节苷脂治疗高原(格尔木)地区新生儿缺氧缺血性脑病(HIE)的临床疗效。方法选择本院2011年1月～2012年6月间收治的新生儿HIE患儿120例随机分为研究组和对照组,每组60例,两组患儿均给予常规治疗,研究组同时加用神经节苷脂。结果 (1)研究组治疗后总有效率为86.7%,明显高于对照组治疗的71.7%(P<0.05)。(2)研究组患儿反射恢复时间、意识恢复时间及肌张力恢复时间均短于对照组(P<0.05)。(3)治疗前两组NBNA评分比较无统计学差异(P>0.05),治疗后两组NBNA评分均显著升高(P<0.05),研究组治疗后NBNA评分显著高于对照组(P<0.05)。结论神经节苷脂能有效提高新生儿缺氧缺血性脑病治疗的临床疗效,在发病率较高的高原(格尔木)地区应用临床效果较好。
Objective To observe the clinical efficacy of ganglioside treatment of neonatal hypoxic-ischemic encephalopathy （HIE） in plateau region （Geermu）. Methods 120 HIE patients of newborns in our hospital from January 2011 to June 2012were randomly divided into the study group and the control group, 60 cases in each group, the two groups were treated with conventional therapy, the study group plus with ganglioside s. Results （1）the total effective rate of study group was 86.7%, the total effective rate of the control group was 71.7% （P 〈 0.05） . （2）The reflex recovery time, recovery time consciousness and recovery time of muscle tone of study group were shorter than the control group （P 〈 0.05）. （3） treatment of the first two groups NBNA score was no significant difference （P 〉 0.05） after treatment the NBNA two sets of scores were significantly higher （P 〈 0.05）, the study group after treatment NBNA score significantly higher than those in the control group （P 〈 0.05）. Conclusion Gangliosides can effectively improve the clinical efficacy of neonatal hypoxic-ischemic encephalopathy treatment, application of good clinical effect in the higher incidence of plateau region（Geermu）.
出处
《中国医药科学》
2013年第8期82-83,共2页
China Medicine And Pharmacy
关键词
新生儿
缺氧缺血性脑病
神经节苷脂
高原
Neonatal
Hypoxic-ischemic encephalopathy
Gangliosides
Plateau
