摘要
目的 研究硝苯地平 (nefedipine) )对小动脉端端吻合后血流速度的影响 ,为血管吻合后临床应用硝苯地平的时间提供依据。方法 取SD大鼠 48只 ,切断左侧颈总动脉后作端端吻合。按术后所给药物的不同随机分成两组。实验组 :术后用硝苯地平灌胃 ( 1.0mg/kg) ;对照组用同等体积生理盐水灌胃。按给药时间又分成术后 2 4、48和 72h 3个给药时间组。每组均在给药后 1、3、5和 7h ,用彩色多普勒超声仪检测左侧颈总动脉吻合口前、吻合口和吻合口后以及右侧颈总动脉收缩期的血流速度。结果 实验组各时间组吻合口前的血流速度增加 ,给药后 3h达到高峰。术后 48h组给药 3h后 ,吻合口血流速度明显增加。术后 48h组给药后 1h ,吻合口后的血流速度明显增加。术后 72h组给药后 1h ,血流速度降低 3 .98%。术后各组血流速度均有增加。结论 硝苯地平可明显增加小动脉行端端吻合术后 ,吻合口前、吻合口后和吻合口的血流速度。在术后 2 4、48和 72h给药均有效果。
Objective To assess the effects of nifedipine on the hemodynamics of the carotid artery after end to end anastomosis, and provide the experimental data for its clinical application.Methods 48 SD rats were involved in the study. The left carotid arteries were transected and anastomosed in an end to end fashion. The rats were randomly divided into two groups postoperatively. In the experimental group, nifedipine was administered intragastrically in a dose of 1.0 mg/kg, while same volume of normal saline was given in the control group. Each group was further divided into three subgroups according to drug delivery time 24 hours, 48 hours, and 72 hours postoperatively. The systolic mean peak velocities (SMPV) of the blood flow in the carotid artery were measured with a color Doppler ultrasonography 1 hour, 3 hours, 5 hours and 7 hours after drug delivery. SMPV was measured at the proximal, distal and anastomotic sites on the left side and at the intact arteries on the right side.Results The velocities at the pre anastomotic sites increased in the three experimental groups, peaking at 3 hours after drug delivery. The velocities at the anastomotic sites significantly increased 3 hours after drug delivery in the 48 hour postoperative group, while the velocities at the post anastomotic sites increased significantly 1 hour after drug delivery in that group. There was a 3.98 % decrease of the velocity 1 hour after drug delivery in the 72 hour postoperative group.Conclusions Nifedipine can remarkably increase blood flow velocities at pre ,post , and anastomotic sites in small arteries after end to end anastomosis. It is effective when given 24 hours, 48 hours, and 72 hours postoperatively.
出处
《中华手外科杂志》
CSCD
2000年第3期187-189,共3页
Chinese Journal of Hand Surgery
基金
国家自然科学基金!资助项目 (392 30 340 1 )
上海市领先学科基金!资助项目 (95 Ⅲ 1 )
关键词
硝苯地平
血管外科手术
血流速度
断指再植
Nifedipine
Vascular surgery
Blood flow velocity
Rats, Spraque Dawley
