摘要
目的 :研究自发性高血压大鼠 (SHR)早期靶器官损伤与红细胞 L -精氨酸转运的关系。方法 :选用 1 2、1 6周龄 SHR,用卡托普利治疗 4周的 1 6周龄SHR和 1 6周龄 WKY大鼠 ,体重 1 80～ 2 95克 ,取心、脑、肾病理检查并测定红细胞 L-精氨酸 (L- Arg)转运。制定靶器官损伤评分标准 ,与红细胞 L- Arg转运作相关分析。结果 :1 6周龄 SHR已出现明显靶器官损伤 ,心、脑、肾重 /体重比、小动脉壁 /腔比均明显大于 WKY组 (P<0 .0 5或 0 .0 1 ) ;心肌细胞肥大、脑小动脉玻璃样变性 ,部分动物心肌细胞变性、坏死 ,冠状动脉硬化。红细胞 L- Arg转运障碍 ,Vmax较WKY组降低 30 % ,P<0 .0 1 ;卡托普利治疗明显改善靶器官损伤 ,并提高红细胞 L- Arg转运能力 ,Vmax较 SHR组上升2 6 .5 % ,P<0 .0 5。靶器官损伤与红细胞 L- Arg转运的 Vmax呈负相关 ,r=- 0 .6 837,P<0 .0 1。结论 :自发性高血压大鼠靶器官损伤程度与红细胞 L-
Aim:To investigate the relationship between early stage target organ damage and erythrocyte L arginine transport in spontaneously hypertensive rats (SHR). Methods:Study was carried out on:SHR untreated group(12 and 16 wks old),SHR captopril treatment group,and WKY(16 wks old). Brain,left ventricle,and kindey in four groups of rats were examined histologically. Transport of L arginine in erythrocytes was measured. Results: In SHR,organ weight to body weight ratio in left ventricle and kidney, arteriolar wall/lumen in brain and left ventricle were increased compared with WKY group( P <0.01 or P <0.05). Light micrography showed obvious target organ damage. The ability of erythrocyte 3H L arginine transport was reduced. In captopril treated group, the target organ damage were obviously improved and the ability of 3H L arginine transport in erythrocyte was enchanced. The V max was increased by 26.5%( P <0.01) compared with 16 weeks SHR untreated group. The V max of 3H L arginine transport in erythrocyte had significantly inversely correlated with the target organ damage degree. Conclusion: There is a negative correlation between the ability of 3H L arginine transport in erythrocytes and target organ damage degree in SHR.
出处
《高血压杂志》
CSCD
2000年第3期262-264,共3页
Chinese Journal of Hypertension
基金
广东省高教厅高校科技三项资助! (981 3)
关键词
高血压
靶器官损伤
红细胞
精氨酸转运
spontaneous hypertension
target organ damage
erythrocyte
L arginine transport
rat
