摘要
目的探讨血小板在椎基动脉缺血性眩晕 (VBI)发病中起的作用及血小板颗粒膜糖蛋白 (GMP140)的临床意义。方法对40例VBI病人进行血浆GMP140 浓度及血小板表面GMP140 分子数测定 ,并同时行TCD检查。结果VBI病人血浆GMP140水平显著高于对照组 (P<0.01) ,血浆GMP140的异常率为70 % ;TCD异常率为67% ;血浆GMP140测定结合TCD检测 ,异常率85%。结论VBI发病过程中存在着血小板的激活及血栓形成倾向 ;血浆GMP140 测定可以作为诊断VBI的一个客观指标 ,结合TCD检查 ,可提高对VBI的诊断水平。
Objective To explore the role of platelet in the ischemic basilar arterial vertigo (VBI) and the clinical value of granule membrane glycoprotein of platelet (GMP140). Methods Measurements of serum GMP140 concentration and the number of GMP140 on the platelet were conducted in 40 VBI cases. TCD was also carried out. Results The serum level of GMP140 in VBI cases was significantly higher than that in the normal cases (P<0.01), while the number of platelets in the VBI cases was much higher than that in the normal cases (P<0.05). The abnormal rate of GMP140 was 70%, TCD abnormal rate was 67%.Conclusion The serum GMP140 could serve as an index in the diagnosis of VBI. When combine with TCD, better diagnosis could be reached.
出处
《浙江临床医学》
2000年第9期595-596,共2页
Zhejiang Clinical Medical Journal
