摘要
从免疫学角度客观评价老年人的腹腔镜手术。方法 :选择 118例年龄大于 6 0岁的慢性胆囊炎胆石症病人随机分成二组 ,LC组 (n =5 8)及OC组 (n =6 0 )分别测定手术前后IL - 2、IL - 6、NK细胞活性、CD4/CD8。结果 :LC组手术前后各项指标无明显变化。OC组与LC组术前免疫指标除NK外均无差异。OC组IL - 2和NK术后较术前下降 ,P <0 .0 5 ,IL - 6术后较术前明显上升 ,P <0 .0 1。IL - 6术后OC组较LC组上升 ,P <0 .0 5。OC组IL - 2术后较LC组降低 ,P <0 .0 5。CD4/CD8未发现明显变化。结论 :在老年病人中 ,从一个侧面反映了LC术后对机体无免疫干扰 ,进而为老年人LC较OC术后较少发生感染性并发症提供了依据。
Objective: To evaluate laparoscopic choleystectomy with immunology in oldman. Methods: The perioperative cellular immunocompeteme of patients undergoing either laparoscopic (n=58) of open (n=60) cholecystectomy was evaluated before operation and at 20 hours after operation. Immune perameters, including IL-2, IL-6, NK cell cytotoxicity. CD4/CD8, were assessed. Results: There were no significant differences in perameters (taball) after laparosiopic cholecystectomy. After open cholecystectomy IL-6 levels were strongly increased, but IL-2 and NK cell cytotoxicity were levels decreased. Comparing with after laparoscopic procedure patients who had indergone open cholecystectomy showed increases of IL-6 reduction of IL-2. Conclusions: This study demonstrates that laparosiopic cholecystectomy preservant of immune function and reduced immune suppression Vs open cholecystectomy in the postoperative period in oldman.
出处
《中国内镜杂志》
CSCD
2000年第4期9-10,共2页
China Journal of Endoscopy
