摘要
目的探讨老年戊型肝炎患者血清ＮＯ、ＭＤＡ、ＳＯＤ与发病的关系。方法采用Ｇｒｉｅｒｓ比色法测定ＮＯ，以ＴＢＡ法测定ＭＤＡ，以分光光度法测定ＳＯＤ。结果老年戊型肝炎患者血清ＮＯ、ＭＤＡ浓度明显高于正常老年对照组（Ｐ＜０．０５），ＳＯＤ明显低于正常老年对照组（Ｐ＜０．０５）。血清胆红素＞８５．５ｎｍｏｌ／Ｌ者与＜８５．５ｎｍｏｌ／Ｌ者血清ＮＯ之间差异无显著性，而血清ＭＤＡ、ＳＯＤ差异有显著性（Ｐ＜０．０５～０．０１）。发生重型肝炎者与未发生重型肝炎者血清ＮＯ、ＭＤＡ、ＳＯＤ均有显著性差异（Ｐ＜０．０５～０．０１）。血清ＮＯ浓度与ＭＤＡ呈负相关（Ｐ＜０．０５），与ＳＯＤ呈正相关（Ｐ＜０．０１），ＳＯＤ浓度与血清ＳＯＤ浓度亦呈负相关（Ｐ＜０．０５）。结论老年成型肝炎患者存在着严重的氧化剂及抗氧化剂失衡状态，脂质过氧化程度及受自由基攻击的程度均较深。ＮＯ、ＭＤＡ、ＳＯＤ失衡在老年成型重型肝炎发病中起一定作用，ＭＤＡ、ＳＯＤ可作为判定老年成型肝炎病情及预后的一种指标。
Aim To determine the effect of NO, MDA and SOD on pathogeny of hepatitis E in aged patients. Methods NO was detected by Griers colorimetry, MDA by TBA method and SOD by spectrophotometry. The serum levels of NO, MDA and SOD were detected in 50 aged patients with hepatitis E. Results The level of SOD was significantly lower (P < 0.05), while NO and MDA were higher (P < 0. 05 ) than those in normal aged controls. There was a postivve correlation between MDA and total bilirubin (TBil) (P < 0.05). There was also a negative correlation between SOD and TBil(P < 0.05). The levels of SOD and NO were significantly low while MDA were elevated in patients who had developed into serious hepatitis (P < 0.05 ~ 0.01 ). There was a postitve correlation between NO and SOD(P < 0 .01 ). There were negative correlations between MDA and NO (P < 0.05) and between MDA and SOD (P < 0.05). Conclusions These results suggested there were unbalance between Oxidation and anti-oxidation which play a role in the pathogeny in aged patients with hepatitis E. MDA and SOD may be as markers which can judge the degree of hepatic injury and prognosis in aged patients with hepatitis E.
出处
《胃肠病学和肝病学杂志》
CAS
2000年第3期203-205,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
老年戊型肝炎
一氧化氮
丙二醛
SOD
aged patients Hepatitis E Nitric oxide(NO) Malonyl- dialdehyde (MDA ) Super oxide dismutase(SOD)
