摘要
目的 通过与传统经典方案CAP的疗效、毒性的比较 ,探讨去甲长春花碱和顺铂 (NP方案 )联合用于非小细胞肺癌 (NSCLC)的新辅助化疗 (NCRT)的可行性。方法 对 30例II期 ,IIIa期NSCLC患者以去NP方案手术前化疗 2个疗程 ,对照组 42例以CAP方案化疗 2个疗程 ,按WHO标准评价临床疗效 ,按WHOO IV度标准评价毒性反应。结果 (1)实验组化疗总缓解率 (RR)为 40 .0 % ,其中CR1例 ,PR 11例 ,对照组RR为 2 8.5 7% ,其中CR0例 ,PR12例。 (2 )NCRT中出现一定程度毒性作用 ,以粒细胞降低为主 ,实验组与对照组虽有差别 ,但无统计学意义。患者恢复迅速 ,全组病例在第二疗程后 3周内手术 ,全部病例能耐受手术 ,未出现围手术期内死亡。结论 去甲长春花碱和顺铂能有效。
Objective:To evaluate the efficacy and safety profile of vinorelbine and displatin combination in treating the patients with non small cell lung cancers (NSCLC)before operation.Methods:30 patients with stage II IIIa NSCLC received two courses of combinations of vinorelbine and cisplatin. Results:(1)Complete response (CR) in 1 patient and partial response in 11 were observed with overall response rate of 40%.Resectional rate was 95.9%.with radial resectional rate 67.5%.(2)Leukopenia was the most frenquent toxicity and the restoration stage is short.All cases can receive surgery in three weeks after last chemotherapy and survived. Conclusion:This study shows that vinorelbine and displatin combination chemotherapy is active and tolerale for the patients with NSCLC in preoperative chemotherapy.
出处
《泰山医学院学报》
CAS
2000年第3期214-215,共2页
Journal of Taishan Medical College
关键词
非小细胞肺癌
药物疗法
新辅助化疗
顺铂
cancer
non small lung/pharmacotherapy
neoadjuvant chemotherapy
