摘要
A series of substituted 2,3-diaryl-2-azabicyclo[2.2.2]octan-5-ones have been prepared by an efficient three-component aza-Diels-Alder cycloaddition reaction in water catalyzed by layered α-zirconium hydrogen phosphate （α-ZrP） and sodium calix[4]arene sulfonates bearing pendant short aliphatic chains. The 18 synthesized compounds were assayed for acetylcholinesterase inhibition using mouse acetvlcho]inesterase.
A series of substituted 2,3-diaryl-2-azabicyclo[2.2.2]octan-5-ones have been prepared by an efficient three-component aza-Diels-Alder cycloaddition reaction in water catalyzed by layered α-zirconium hydrogen phosphate （α-ZrP） and sodium calix[4]arene sulfonates bearing pendant short aliphatic chains. The 18 synthesized compounds were assayed for acetylcholinesterase inhibition using mouse acetvlcho]inesterase.
基金
financial support from the Natural Science Foundation of China(No.21176222)
