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Neamine-heterocycle conjugates as potential anti-HIV agents

Neamine-heterocycle conjugates as potential anti-HIV agents
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摘要 A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV activity than neomycin B. The results suggested that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents. A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV activity than neomycin B. The results suggested that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents.
作者 Ri-Bai Yan Yan-Fen Wu Jun Liu Xiao-Lian Zhang Xin-Shan Ye
机构地区 State Key Laboratory of Natural and Biomimetic Drugs State Key Laboratory of Virology
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2013年第4期273-278,共6页 中国化学快报（英文版）
基金 financially supported by the Ministry of Science and Technology of China(Nos.2012ZX09502001-001, 2012CB822100,and 2012CB720604) the National Natural Science Foundation of China(Nos.81025008 and 30921001)
关键词 AMINOGLYCOSIDE ANTI-HIV Neamine SYNTHESIS AminoglycosideAnti-HIVNeamineSynthesis
分类号 TQ460.1 [化学工程—制药化工]
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参考文献35

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Chinese Chemical Letters
2013年 第4期

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