摘要
Dougherty和Conway的转化医学“3T”模式体现了T1（基础研究到临床有效性研究）、他（临床有效性研究到临床疗效研究）、仍（临床疗效研究到与经济有关的研究和改进医疗服务质量）阶段的相互转化过程，可作为测量转化研究的基础框架。文献之间的引用与被引用关系形成的“引文网络（citationnetwork）”揭示出具体领域的转化地带、转化路径和转化时滞，可使科研人员把握该领域转化研究的关键内容与路线图，促进研究从上游吸收和向下游转化，最终加速转化医学进程。利用文献的引文网络可对不同研究阶段之间的转化关系进行测量。本文基于文献“引文网络”分析方法，介绍“3T”模式下的转化研究测量模型。
The ＂3T＂ road map proposed by Dougherty and Conway views translational research as a con- tinuous process that moves from basic research through clinical （ T1 ）, postclinieal （ T2 ）, and practice-based research and ultimately to health policies, outcomes, and impacts （T3）. It can be used as a fundamental framework for evaluating and measuring translational research. The citation networks between publications may reveal translational interfaces, translational path, and translational lag in a specific research field, which can help researchers understand the critical content and road maps during their translational research, and thus ac- celerate translational medicine during T1, T2, and T3 phases of translational research. Based on the citation networks, we buih a two-dimensional model for measuring the process of translational research.
出处
《中华临床营养杂志》
CAS
CSCD
2013年第2期98-102,共5页
Chinese Journal of Clinical Nutrition
基金
中央级公益性科研院所基本科研业务费专项（IOR0111、11R0212、12R0123）,国家科技图书文献中心面向“重大新药创制”、“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项的专业化信息服务专项课题（2012XM25、2012XM26）和吴阶平基金会科研基金（2009-2012#3206-7500-9107）
关键词
3T模式
转化研究
引文网络
＂3T＂ translational research model
Translational research
Citation network
