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青少年妇科恶性肿瘤患者治疗后生理、生育功能保护及预后 被引量：4

Fertility-sparing management among adolescents and young women with gynecologic malignancies
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摘要 青少年恶性肿瘤患者保留生育手术后,辅助化疗会导致卵巢功能损害。严重者发生早绝经。不同化疗药物、接受化疗的年龄、单次及累积剂量影响受损程度。预防卵巢早衰主要手段包括:使用GnRHa、自体或异体卵巢移植、性激素替代治疗补救。肿瘤生殖学领域的大量难题尚待大规模的深入研究。 Chemotherapies after fertility preserved surgeries among adolescents and young women with gynecologic malignancies may induce damages of ovarian function. A comparatively part of them is severe cases which induce premature ovarian failure （POF）. The composition of chemical, the age of receiving chemotherapies and the dose of drugs are main factors. The possibilities to preserve fertility in women exposed to chemotherapy are：the administration of a gonadotropin-releasing hormone （GnRH） agonist, autogenously or exogenous ovarian transplantation and hormone replacement treatment. 
作者 王朝华 崔恒
机构地区 北京大学人民医院妇科
出处 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 2013年第5期339-342,共4页 Chinese Journal of Practical Gynecology and Obstetrics
关键词 恶性肿瘤 化疗 卵巢功能 生殖 卵巢早衰 malignancies chemotherapies ovarian function fertility premature ovarian failure
分类号 R711.74 [医药卫生—妇产科学]
  • 相关文献

参考文献21

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二级参考文献51

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共引文献22

同被引文献48

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引证文献4

二级引证文献20

中国实用妇科与产科杂志
2013年 第5期

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