摘要
目的探讨血浆同型半胱氨酸（Hcy）与老年冠心病合并骨质疏松的关系。方法98例老年冠心病患者按照骨密度（BMD）平均T值分为三组：骨质疏松组（A组）29例，骨量减少组（B组）37例及骨量正常组（c组）32例。另选取健康对照组（D组）25例，分别比较各组收缩压（SBP）、舒张压（DBP）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL—C）、高密度脂蛋白胆固醇（HDL。C）、总胆固醇（TC）、体质量指数（BMI）、Hcy、血钙、血磷及超敏C．反应蛋白（hs—CRP）水平。结果A组和B组Hcy水平明显高于C组和D组，且A组高于B组，C组高于D组（P〈0．05）；血浆Hcy水平与BMD呈负相关（r=-0．581，P〈0．05）；BMI与骨质疏松是影响Hcy的重要因素（回归系数bl=-0．68，b2=3．459，P〈0．05）。结论老年冠心病合并骨质疏松患者血浆Hcy升高可能与其BMD减低有关，Hcy水平可能为老年冠心病患者骨质疏松的独立危险因素之一。
Objective To investigate the relationship between plasma homocysteine （Hcy） and elderly coronary heart disease patients with osteoporoisis. Methods Ninety-eight elderly patients with coronary heart disease were divided into three groups according to the average T value of bone mineral density（BMD） ： patients in group A（29 cases） were osteoporosis group, patients in group B（37 cases） were osteopenia group, and patients in group C （32 cases） were normal group. Twenty-five healthy cases as normal control group（group D）. SBP, DBP, TG, LDL-C, HDL-C, TC, BMI, Hcy, blood calcium, blood phosphorus and hs-CRP levels were compared among the four groups. Results Levels of plasma Hcy in group A and group B were higher than those in group C and group D, and that in group A was higher than that group B, in group C was higher than that in group D（ P 〈 0.05）. BMD was negatively correlated with plasma Hcy（ r = -O. 581, P 〈 0.05）. BMI and osteoporosis were the risk factors that affected Hcy（bl = -0. 68, b2 =3. 459, P 〈0.05）. Conclusions Elevated plasma Hcy levels in eld- erly coronary heart disease patients with osteoporosis may be correlated with the decrease of BMD. Hcy level may be independent risk factor for osteoporosis in coronary heart disease patients.
出处
《中国实用医刊》
2013年第10期1-3,共3页
Chinese Journal of Practical Medicine
关键词
同型半胱氨酸
冠心病
骨质疏松
老年
骨密度
Homocysteine
Coronary heart disease
Osteoporosis
Elderly
Bone mineraldensity
