摘要
目的探讨不同麻醉方法对老年上腹部肿瘤手术患者应激反应的作用。方法将2008年9月至2011年3月收治的105例老年上腹部肿瘤患者根据随机数字表分为硬膜外阻滞组、单纯全身麻醉组和硬膜外阻滞加全身麻醉组,每组各35例,于手术前后测定三组患者肾上腺素、去甲肾上腺素、皮质醇、白细胞介素6和白细胞介素8含量,探讨不同方法对其神经应激反应的影响。结果硬膜外阻滞加全身麻醉组患者其肾上腺素、皮质醇、白细胞介素6和白细胞介素8指标较手术前无明显变化(P>0.05),去甲肾上腺素指标显著上升(P<0.05);其余两组患者观察指标均明显上升(P<0.05)。结论硬膜外阻滞加全身麻醉对比硬膜外阻滞和单纯全身麻醉显示出了良好的安全性,在应激反应的控制方面显著优于后者,尤其是对于身体状况较差且患有严重疾患的老年人,能够起到保持机体器官稳定、改善预后等作用,值得临床广泛推广。
Objective To explore the different methods of anesthesia on stress reaction in elderly patients with abdominal tumor operation on the role. Methods 105 patients in our hospital from September 2008 to March 2011 admitted to the upper abdominal tumor patients were grouped according to the random number table, where in the epidural anesthesia group, simple general anesthesia and epidural block com- bined with general anesthesia group with 35 cases in each group, the 3 groups of patients before and after operation of epinephrine, norepinephrine, cortisol, IL-2, IL-6 and IL-8 content determination method, to explore the different effect on the neural stress response. Results Epidural block combined with general anesthesia of patients whose adrenaline, cortisol, IL-6 and IL-8 indicator than before operation had no sig- nificant change （ P 〉 0. 05 ）, significantly increased norepinephrine index （ P 〈 0. 05 ） ; the remaining two observation indexes were significantly increased （P 〈 0. 05 ）. Conclusions Epidural block combined with general anesthesia of epidural block, general anesthesia showed good safety, significantly higher than in the control of the stress response of the latter, especially for the poor physical condition and is suffering from a serious disease of the elderly, to keep the body organs, improve the prognosis of stable effect, is worthy of clinical application.
出处
《中国肿瘤临床与康复》
2013年第4期356-358,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
