摘要
为探讨调神方 (由党参、桂枝、远志、茯苓等组成 )对Alzheimer (AD)病的作用机理 ,造成类AD大鼠模型 ,以Y -电迷宫和ELISA法分别观察该方对模型大鼠学习记忆行为和血清细胞因子IL -2、TNF -α、INF -γ水平的影响。结果 :调神方可显著提高痴呆大鼠Y -迷宫正确次数 ,明显降低痴呆大鼠升高的血清IL -2、TNF -α含量。
In order to investigate the mechanism of “Spirit-Regulating Formula” (composed of Radix Codonopsis Pilosulae, Ramulus Cinnamomi, Radix Polygalae, Poria, etc.) in Alzheimer disease (AD), AD-like rat models were made to observe influence of this formula on learning and memory behavior and serum cellular factor IL-2, TNF-α and INF-γ in rat model, by electric labyrinth and ELISA respectively. The results showed that “Spirit-Regulating Formula” could remarkably enhance the correct times in electric labyrinth and decrease obviously the enhanced serum IL-2 and TNF-γ in AD rats. The finding indicates that “Spirit-Regulating Formula” can enhance the learning and memory ability of AD rats by improving the immune status.
出处
《上海中医药大学学报》
CAS
2000年第3期42-44,共3页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
"九五"国家重大攻关项目!(96 -90 6 -0 9-0 1)
关键词
调神方
大鼠
学习记忆
细胞因子
早老性痴呆
Spirit-Regulating Formula"
Alzheimer disease (AD)
AD-like rat model
learning and memory
cellular factor
