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老年晚期非小细胞肺癌靶向治疗进展

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摘要 近年来,分子靶向药物已广泛应用于非小细胞肺癌的临床治疗中,由于此类药物可作用于特定的靶点,因此无细胞毒药物所出现的明显毒副反应,用药安全性较好,它们比细胞毒药物更适合应用于老年患者。现就近年来靶向治疗药物在老年非小细胞肺癌患者中的治疗应用综述如下。
作者 张卉 张树才
出处 《结核病与胸部肿瘤》 2012年第3期227-229,共3页 Tuberculosis and Thoracic Tumor
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参考文献19

  • 1Crin6 L. Cappuzzo F. Zatloukal P,et,al. Gefitinib versus vinorelbine inchemotherapy-naive elderly patients with advanced non-small-cell lungcancer (INVITE): a randomized, phase II study. J Clin Oncol, 2008.26(26): 4253-4260.
  • 2Ebi N, Semba H, Tokunaga SJ, Takayama K,et al. A phase II trial ofgefitinib monotherapy in chemotherapy-naive patients of 75 years or olderwith advanced non-small cell lung cancer. J Thorac Oncol, 2008, 3(10):1166-1171.
  • 3张力,王淑兰,张晓彤,李龙芸,王孟昭.吉非替尼单药治疗老年晚期非小细胞肺癌患者的临床观察[J].中华内科杂志,2007,46(5):392-395. 被引量:10
  • 4刘晓晴,汤传昊,鲍云华,高红军,李俭杰,王维威,李晓燕.吉非替尼治疗老年晚期非小细胞肺癌57例临床分析[J].中华老年多器官疾病杂志,2008,7(1):40-42. 被引量:11
  • 5姜宏宁,史崑,余敏.吉非替尼一线治疗老年非小细胞肺癌的临床观察[J].实用癌症杂志,2008,23(4):402-405. 被引量:8
  • 6Y. Minegishi, M. Maemondo,S. Okinaga, et al. First-line gefitinib therapyfor elder advanced non-small cell lung cancer patients with epidermalgrowth factor receptor mutations: Multicenter phase II trial (NEJ 003study). J Clin Oncol . 2010, 28:15s, (suppl; abstr 7561).
  • 7S. Fujita,N. Katakami, K. Masago, et al. A phase II study of gefitinibversus vinorelbine or gemcitabine in chemotherapy-naive elderly patientswith advanced non-small cell lung cancer based on epidermal growthfactor receptor mutation status. J Clin Oncol , 2010, 28: 15s,(supp 1;abstr 7559).
  • 8Jackman DM, Yeap BY, Lindeman NI,et al. Phase II clinical trial ofchemotherapy-naive patients > or = 70 years of age treated with erlotinibfor advanced non-small-cell lung cancer. J Clin Oncol, 2007, 25(7): 760-766.
  • 9Wheatley-Price P,Ding K, Seymour L,et al. Erlotinib for advanced non-small-cell lung cancer in the elderly: an analysis of the National CancerInstitute of Canada Clinical Trials Group Study BR.21. J Clin Oncol,2008,26(14): 2350-2357.
  • 10LeCaer H,Barlesi F, Corre R,et al. A multicentre phase II randomizedtrial of weekly docetacel/gemcitabine followed by erlotinib onprogression, vs the reverse sequence, in elderly patients with advancednon small-cell lung cancer selected with a comprehensive geriatricassessment (the GFPC 0504 study). British Journal of Cancer,2011,105(8): 1123-1130.

二级参考文献38

  • 1王彬,张湘茹,储大同.易瑞沙在晚期非小细胞肺癌化疗失败后的作用[J].中华肿瘤杂志,2004,26(12):742-745. 被引量:53
  • 2王岩,徐建明,宋三泰.表皮生长因子受体靶向药物作用机制与相关标志物的研究现状[J].中华肿瘤杂志,2005,27(9):573-576. 被引量:33
  • 3刘晓晴,汤传昊,高红军,李俭杰,王维威.靶向药物吉非替尼单药治疗晚期非小细胞肺癌[J].军事医学科学院院刊,2006,30(5):447-449. 被引量:8
  • 4[1]Fukuoka M,Yano S,Giaccone G,et al.Multi-institutional randomized phase Ⅱ trial of gefitinib for previously treated patients with advanced non-small-celllung cancer(The IDEAL I Trial).J Clin Oncol,2003,21:2237-2246.
  • 5[2]Douillard JY,Giaccone G,Horai T,et al Improvement in disease-related symptoms and quality of life in patients with advanced non-small-cell lunng cancer (NSCLC) treated with ZDl839 (Iressa)(IDEAL 1).Proc Am Soc Clin Oncol,2002,21:1195.
  • 6[3]Kris MG,Natale RB,Herbst RS,et al.Efficacy of gefitinib,an inhibitor of the epidermal growth factor receptor tyrosine kinase,in symptomatic patients with non-small-cell lung cancer:a randomized trial.JAMA,2003,290:2149-2158.
  • 7[4]Natale RB,Skarin AT,Maddox AM,et al.Improvement in symptoms and quality of life for advanced nonsmall-cell lung cancer patients receiving ZDl839 (IDEAL 2).Proc Am Soc Clin Oncol,2002,21:1167.
  • 8[5]The Elderly Lung Cancer Vinorelbine Italian Study Group.Effects of vinorelbine on quality of life and survival of elderly patients with advanced non small cell lung cancer.J Natl Cancer Inst,1999,91:66-72.
  • 9[6]Gridelh C,Cigolan S,Gallo C,et al.MIL ES investigators.Activity and toxicity of gemcitabine and gemcitabine +vinorelbine in advanced non small cell lung cancer elderly patients:a phaseⅡ data from multicenter Italian lung cancer in the elderly study (MILES)randomized trial.Lung Cancer,2001,31:277-284.
  • 10[7]Quoix E,Breton JL,Ducolone A,et al.First linechemotherapy with gemcitabine in advanced non small cell lung cancer elderly patients:a randomized phaseⅡ study of 3-week versus 4-week schedule.Lung Cancer,2005,47:405-412.

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