老年晚期非小细胞肺癌靶向治疗进展
摘要
近年来,分子靶向药物已广泛应用于非小细胞肺癌的临床治疗中,由于此类药物可作用于特定的靶点,因此无细胞毒药物所出现的明显毒副反应,用药安全性较好,它们比细胞毒药物更适合应用于老年患者。现就近年来靶向治疗药物在老年非小细胞肺癌患者中的治疗应用综述如下。
出处
《结核病与胸部肿瘤》
2012年第3期227-229,共3页
Tuberculosis and Thoracic Tumor
参考文献19
-
1Crin6 L. Cappuzzo F. Zatloukal P,et,al. Gefitinib versus vinorelbine inchemotherapy-naive elderly patients with advanced non-small-cell lungcancer (INVITE): a randomized, phase II study. J Clin Oncol, 2008.26(26): 4253-4260.
-
2Ebi N, Semba H, Tokunaga SJ, Takayama K,et al. A phase II trial ofgefitinib monotherapy in chemotherapy-naive patients of 75 years or olderwith advanced non-small cell lung cancer. J Thorac Oncol, 2008, 3(10):1166-1171.
-
3张力,王淑兰,张晓彤,李龙芸,王孟昭.吉非替尼单药治疗老年晚期非小细胞肺癌患者的临床观察[J].中华内科杂志,2007,46(5):392-395. 被引量:10
-
4刘晓晴,汤传昊,鲍云华,高红军,李俭杰,王维威,李晓燕.吉非替尼治疗老年晚期非小细胞肺癌57例临床分析[J].中华老年多器官疾病杂志,2008,7(1):40-42. 被引量:11
-
5姜宏宁,史崑,余敏.吉非替尼一线治疗老年非小细胞肺癌的临床观察[J].实用癌症杂志,2008,23(4):402-405. 被引量:8
-
6Y. Minegishi, M. Maemondo,S. Okinaga, et al. First-line gefitinib therapyfor elder advanced non-small cell lung cancer patients with epidermalgrowth factor receptor mutations: Multicenter phase II trial (NEJ 003study). J Clin Oncol . 2010, 28:15s, (suppl; abstr 7561).
-
7S. Fujita,N. Katakami, K. Masago, et al. A phase II study of gefitinibversus vinorelbine or gemcitabine in chemotherapy-naive elderly patientswith advanced non-small cell lung cancer based on epidermal growthfactor receptor mutation status. J Clin Oncol , 2010, 28: 15s,(supp 1;abstr 7559).
-
8Jackman DM, Yeap BY, Lindeman NI,et al. Phase II clinical trial ofchemotherapy-naive patients > or = 70 years of age treated with erlotinibfor advanced non-small-cell lung cancer. J Clin Oncol, 2007, 25(7): 760-766.
-
9Wheatley-Price P,Ding K, Seymour L,et al. Erlotinib for advanced non-small-cell lung cancer in the elderly: an analysis of the National CancerInstitute of Canada Clinical Trials Group Study BR.21. J Clin Oncol,2008,26(14): 2350-2357.
-
10LeCaer H,Barlesi F, Corre R,et al. A multicentre phase II randomizedtrial of weekly docetacel/gemcitabine followed by erlotinib onprogression, vs the reverse sequence, in elderly patients with advancednon small-cell lung cancer selected with a comprehensive geriatricassessment (the GFPC 0504 study). British Journal of Cancer,2011,105(8): 1123-1130.
二级参考文献38
-
1王彬,张湘茹,储大同.易瑞沙在晚期非小细胞肺癌化疗失败后的作用[J].中华肿瘤杂志,2004,26(12):742-745. 被引量:53
-
2王岩,徐建明,宋三泰.表皮生长因子受体靶向药物作用机制与相关标志物的研究现状[J].中华肿瘤杂志,2005,27(9):573-576. 被引量:33
-
3刘晓晴,汤传昊,高红军,李俭杰,王维威.靶向药物吉非替尼单药治疗晚期非小细胞肺癌[J].军事医学科学院院刊,2006,30(5):447-449. 被引量:8
-
4[1]Fukuoka M,Yano S,Giaccone G,et al.Multi-institutional randomized phase Ⅱ trial of gefitinib for previously treated patients with advanced non-small-celllung cancer(The IDEAL I Trial).J Clin Oncol,2003,21:2237-2246.
-
5[2]Douillard JY,Giaccone G,Horai T,et al Improvement in disease-related symptoms and quality of life in patients with advanced non-small-cell lunng cancer (NSCLC) treated with ZDl839 (Iressa)(IDEAL 1).Proc Am Soc Clin Oncol,2002,21:1195.
-
6[3]Kris MG,Natale RB,Herbst RS,et al.Efficacy of gefitinib,an inhibitor of the epidermal growth factor receptor tyrosine kinase,in symptomatic patients with non-small-cell lung cancer:a randomized trial.JAMA,2003,290:2149-2158.
-
7[4]Natale RB,Skarin AT,Maddox AM,et al.Improvement in symptoms and quality of life for advanced nonsmall-cell lung cancer patients receiving ZDl839 (IDEAL 2).Proc Am Soc Clin Oncol,2002,21:1167.
-
8[5]The Elderly Lung Cancer Vinorelbine Italian Study Group.Effects of vinorelbine on quality of life and survival of elderly patients with advanced non small cell lung cancer.J Natl Cancer Inst,1999,91:66-72.
-
9[6]Gridelh C,Cigolan S,Gallo C,et al.MIL ES investigators.Activity and toxicity of gemcitabine and gemcitabine +vinorelbine in advanced non small cell lung cancer elderly patients:a phaseⅡ data from multicenter Italian lung cancer in the elderly study (MILES)randomized trial.Lung Cancer,2001,31:277-284.
-
10[7]Quoix E,Breton JL,Ducolone A,et al.First linechemotherapy with gemcitabine in advanced non small cell lung cancer elderly patients:a randomized phaseⅡ study of 3-week versus 4-week schedule.Lung Cancer,2005,47:405-412.
共引文献22
-
1艾斌,程刚.老年晚期非小细胞肺癌的药物治疗[J].中国医学科学院学报,2010,32(4):473-476.
-
2武晓楠,王征,丁丽,李旭,赵赟博.老年非小细胞肺癌患者表皮生长因子受体基因19—21外显子突变研究[J].中华老年医学杂志,2008,27(10):731-735. 被引量:2
-
3周京旭,林丽珠.老年肺癌的中西医治疗策略[J].中国中西医结合杂志,2008,28(12):1133-1136. 被引量:4
-
4苟静玲.2004~2007年我院门诊消耗金额前50位药品应用分析[J].中国医院用药评价与分析,2009,9(4):250-253. 被引量:2
-
5王敬慧,张树才.老年晚期非小细胞肺癌的靶向治疗[J].中国肺癌杂志,2009,12(7):821-825. 被引量:7
-
6杨兰平,梁嵘,黄汉生.吉非替尼治疗老年晚期非小细胞肺癌55例[J].中国肿瘤临床,2009,36(21):1225-1226.
-
7曲俊兵.吉非替尼药品不良反应分析[J].中国药房,2010,21(2):162-164. 被引量:17
-
8刘晓,王晖,武晓楠,周美珍.吉非替尼治疗老年人晚期肺癌骨转移一例[J].中华老年医学杂志,2010,29(1):80-81.
-
9杨国林,林伟,王继成,陆茵.吉非替尼治疗老年晚期非小细胞肺癌临床观察[J].临床合理用药杂志,2010,3(3):7-8. 被引量:1
-
10李小瑞,崔艳慧,张清琴,花勤亮.吉非替尼治疗晚期非小细胞肺癌疗效及相关因素分析[J].中华肿瘤防治杂志,2009,16(23):1881-1883. 被引量:4
-
1郭亮,苏克莉,牛建花,牛学才.多西他赛单药化疗与联合铂类一线治疗老年晚期非小细胞肺癌的有效性与安全性研究[J].中国社区医师,2015,31(12):38-39. 被引量:6
-
2许尤琪,张玉,徐建伟.紫杉醇脂质体经动脉介入治疗恶性肿瘤32例疗效观察[J].中国医药,2008,3(12):786-787. 被引量:4
-
3任庆涛.生长抑素类似物奥曲肽在胃癌治疗中的应用效果观察[J].中国实用医药,2015,10(15):164-165. 被引量:5
-
4宋敏,王留兴.单药健择与联合方案治疗老年晚期非小细胞肺癌的临床观察[J].河南肿瘤学杂志,2004,17(5):332-333. 被引量:2
-
5梁兴林,吴炜,夏瑞祥.氟达拉滨联合环磷酰胺治疗慢性淋巴细胞白血病30例疗效观察[J].安徽医学,2013,34(9):1354-1355. 被引量:4
-
6辛小海.急性早幼粒细胞性白血病并发中枢神经系统白血病的临床分析[J].基层医学论坛,2016,20(32):4543-4544. 被引量:3
-
7徐亚平,李芳.不同剂量米非司酮治疗子宫肌瘤效果观察[J].中国乡村医药,2016,23(22):18-19. 被引量:2
-
8张波.培美曲塞联合顺铂二线治疗晚期肺腺癌的临床研究[J].中国医药指南,2012,10(32):62-63.
-
9陈世壮,董桂芝,方晓敏,白艳春,刘静.健择联合卡铂治疗中晚期非小细胞肺癌的临床研究[J].中国肿瘤临床与康复,2007,14(5):440-441.
-
10张炎,吴仕和,郭晓东,王育红,刘刚.替吉奥联合奥沙利铂及多西紫杉醇治疗晚期胃癌的临床疗效和安全性评估[J].现代生物医学进展,2014,14(11):2076-2078. 被引量:12