摘要
目的:研究肾康注射液(SKI)对腹膜透析液(peritoneal dialysis solution,PDS)诱导的大鼠腹膜透析功能减退及氧化应激的影响。方法:50只SD大鼠,随机分为正常对照组、4.25%PDS组和SKI低、中、高剂量(SKI组都加入4.25%PDS)组,8周后进行腹膜功能实验,量取透出液体积,腹主动脉取血检测血清中的超氧化物歧化酶(SOD)、丙二醛(MDA)的含量,并计算超滤量(UF)、葡萄糖转运量(MTG)及葡萄糖清除率(C)。结果:与PDS组比较,SKI中、高剂量组的UF、C、SOD含量显著增加(P<0.05),SKI各剂量组的MTG、MDA含量显著下降(P<0.05)。结论:腹膜透析液中加入SKI具有改善PDS诱导的腹膜透析功能减退和抑制氧化应激的作用。
Objective： To investigate the influence of Shen Kang injection （SKI） on decrease of peritoneal dialysis effect caused by peritoneal dialysis solution （PDS） and oxidative stress in rats. Methods： Fifty SD rats were randomly divided into normal control group, 4.25% PDS group, and groups of 4.25% PDS ＋ low, moderate and high doses of SKI respectively. Peritoneal function test was performed in rats of each group in 8 weeks after intraperitoneal injection with PDS or/and SKI. The volume of peritoneal effluent was detected, and blood samples were taken from abdominal aorta. Serum levels of superoxide dismutase （ SOD）, malondialdehyde （MDA） were measured. Ultrafihratian amount （UF）, mass transfer amount of glucose ＇（MTG） and clearance rates of glucose （C） were detected. Results： UF, C and serum levels of SOD in SKI groups were higher than those in group PDS （P 〈 0.05）. Serum levels of MDA and MTG in SKI groups were lower than those in group PDS （P 〈 0. 05）. Conclusions： SKI may be helpful in ameliorating peritoneal dialysis function decrease caused by PDS and inhibiting oxidative stress in peritoneal dialysis rats.
出处
《贵阳医学院学报》
CAS
2013年第2期138-140,共3页
Journal of Guiyang Medical College
基金
贵州省科学技术基金项目(黔科合J字[2011]2252号)
