摘要
脓毒症引起的器官功能障碍，仍是临床上严重危及生命的棘手问题，是导致急危重症患者高病死率的主要原因。失代偿性炎症反应和免疫功能障碍等一系列复杂的反应严重损害了机体有效清除病原微生物的能力^[1]。
Sepsis is a systemic inflammatory response syndrome resulting from a host response to infection. The early stage of sepsis is characterized by excessive inflammatory response, accompanied by immune dysfunction characterized by aggravating cellular immunosuppression. The vast majority of patients with sepsis survive the initial excessive inflammatory response, but die of hospitalacquired infection, opportunistic pathogenic bacteria infection, latent virus reactivation, and multiple organ dysfunction syndrome. These facts indicate that immunosuppression may be a significant cause of exacerbation of the illness even death of the septic patients. The primary cellular mechanisms in inducing immune dysfunction include immune dysfunction of T lymphocytes, negative regulation of regulatory T lymphocytes and dendritic cells, and damage of intestinal mucosa associated lymphoid tissue. Xuebijing injection is a complex Chinese patent medicine, which is widely used in the treatment of sepsis. It has a potential immunoregulation ability, as well as effects on bacteriostasis, antiendotoxin and antiinflammation. Its target and mechanism of action need to be explored further.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2013年第2期162-165,共4页
Chinese Journal of Burns
基金
国家自然科学基金（81071545、81130035）
国家重点基础研究发展il-~JJ（2012CB518102）
全军“十二五”汁划重大项目（AWSl1J008）
关键词
免疫
脓毒症
血必净注射液
治疗
Immunity
Sepsis
Xuebijing injeetion
Treatment
