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S期激酶相关蛋白和p27^kip1在贲门腺癌中的表达及其临床意义 被引量：2

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摘要 消化道肿瘤是严重威胁人类健康的恶性肿瘤之一，贲门位于胃食管交界处，此处发生恶性病变，有其特殊的分子生物学特点。S期激酶相关蛋白（S-phase kinase associated protein2，Skp2）作为F-box蛋白家族一员，是细胞进入S期的重要调控蛋白，它通过启动泛素蛋白酶降解途径特异性识别底物，进而参与细胞周期的调控。
作者 陶雪梅 张国梁 鲍文漪
机构地区 天津医科大学一中心临床学院
出处 《中华消化内镜杂志》 2013年第4期223-226,共4页 Chinese Journal of Digestive Endoscopy
关键词 S期激酶相关蛋白 P27^KIP1 贲门腺癌 临床意义 分子生物学特点 F-BOX蛋白 调控蛋白 细胞周期
分类号 R735 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Wang G, Chan CH, Gao Y,et al. Novel roles of Skp2 E3 ligasein cellular senescence,cancer progression,and metastasis. ChinJ Cancer, 2012,31 : 169-177.
  • 2Molatore S, Kierraaier E, Jung CB, et al. Characterization of anaturally-occurring p27 mutation predisposing to multiple endo-crine tumors. Mol Cancer, 2010,9 : 116.
  • 3Gstaiger M, Jordan R, Lim M, et al. Skp2 is oncogenic andoverexpressed in human cancers. Proc Natl Acad Sci U S A,2001,98:5043-5048.
  • 4Chan CH, Lee SW, Wang J, et al. Regulation of Skp2 expres-sion and activity and its role in cancer progression. ScientificWorld J,2010,10:1001-1015.
  • 5Rose AE, Wang G, Hanniford D, et al. Clinical relevance ofSKP2 alterations in metastatic melanoma. Pigment Cell MelanomaRes, 2011,24:197-206.
  • 6Liang Y, Hou X, Cui Q, et al. Skp2 expression unfavorably im-pacts survival in resectable esophageal squamous cell carcinoma.J Transl Med, 2012,10:73.
  • 7Lee J, Kim SS. The function of p27 KIP1 during tumor develop-ment. Exp Mol Med, 2009,41:765-771.
  • 8Hershko DD. Cyclin-dependent kinase inhibitor p27 as a prog-nostic biomarker and potential cancer therapeutic target. FutureOncol, 2010,6:1837-1847.
  • 9Miyamoto T, Horiuchi A, Kashima H, et al. Inverse correlationbetween Skp2 and p27 ( Kipl ) in normal endometrium and endo-metrial carcinoma. Gynecol Endocrinol, 2010,26:220-229.

同被引文献29

  • 1宋旭东,李志强,朱海燕.P27^(kip1)和Skp2在食管癌中的表达[J].第四军医大学学报,2007,28(1):21-23. 被引量：9
  • 2张肖肖,辛彦.Ezrin蛋白与肿瘤转移关系的研究进展[J].中国肿瘤临床,2007,34(23):1377-1380. 被引量：7
  • 3Joseph TT,Budania LS,Rao AK,et al.Self-expanding metal stentsfor esophageal perforation with nasogastric tube insertion in e-sophageal carcinoma [ J ] . Saudi J Anaesth,2015,9(1): 108-109.
  • 4Simon E, Martin D, Johan L, et al. Esophageal cancer : currentand emerging therapy modalities [ J ]. Expert Rev AnticancerTher,2008,8(9) : 1433-1448.
  • 5Wang GC,Chan CH,Gao Y,et al. Novel roles of Skp2 E3 ligasein cellular senescence,cancer progression,and metastasis [ J ].Chin J Cancer,2012,31(4) :169-177.
  • 6Sistrunk C, Kim SH, Wang X,et al. Skp2 deficiency inhibitschemical skin tumorigenesis independent of p27(Kipl) accumu-lation [J]. Am J Pathol,2013,182(5):1854-1864.
  • 7Luo Y,Xu DQ,Dong HY,et al. Tanshinone H A inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation viaAkt/Skp2/p27-associated pathway [ J/OL ]. PLoS One, 2013, 8(2 ) [ 2015-04-25 ]. http://www. ncbi. nlm. nih. gov/pubmed/23437233.
  • 8Li B, Lu W, Yang Q, et al. Skp2 regulates androgen receptorthrough ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate cancer[ J]. Prostate, 2014,74(4) ??421-432.
  • 9Chen TP, Chen CM, Chang HW, et al. Increased expression ofSKP2 and phospho-MAPK/ERKl/2 and decreased expression ofp27 during tumor progression of cervical neoplasms [ J ].Oncology,2007,104(3) :516-523.
  • 10Wang XC’Tian LL,Tian J, et al. Overexpression of SKP2 pro-motes the radiation resistance of esophageal squamous cell carci-.

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中华消化内镜杂志
2013年 第4期

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