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磁共振动态增强扫描成像评价辛伐他汀治疗兔动脉粥样硬化斑块的疗效 被引量：3

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摘要 目的探讨磁共振动态增强扫描成像(DCE-MRI)在辛伐他汀治疗动脉粥样硬化斑块疗效评价中的应用价值。方法选择成年雄性新西兰大白兔30只,随机分为高脂喂养+药物治疗组和高脂喂养组,每组15只。均给予高脂饮食,喂养16 w后,高脂喂养+药物治疗组在高脂饲料中加用辛伐他汀喂养至第20周。测定DCE-MRI动脉粥样硬化斑块时间-信号强度曲线参数。使用免疫组化方法标记斑块内巨噬细胞、新生血管内皮细胞。结果两组高脂喂养后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)均明显升高,第8、16周两组间比较无显著差异,第20周高脂喂养组血脂水平明显高于高脂喂养+药物治疗组。高脂喂养组动脉粥样硬化斑块内CD31、CD68染色阳性细胞百分比明显高于高脂喂养+药物治疗组。高脂喂养+药物治疗组15只实验兔共检出36处强化动脉粥样硬化斑块,增强扫描均可见强化;高脂喂养组15只实验兔共检出40处强化动脉粥样硬化斑块,增强扫描均可见强化。高脂喂养+药物治疗组首过时相斜率S、斑块最大强化率Smax、斑块峰值信号强度强化后120 s信号强度下降率Soutflow均低于高脂喂养组。结论 DCE-MRI参数S、Soutflow、Smax可以作为一种评价药物治疗动脉粥样硬化斑块疗效的量化指标。
作者 刘铁军 曲晓峰 宫艳玲 刘书峰
机构地区 鄂尔多斯市康巴什新区医疗急救中心 大连医科大学附属二院放射科 大连大学附属中山医院放射科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2013年第8期1858-1859,共2页 Chinese Journal of Gerontology
关键词 磁共振动态增强扫描 辛伐他汀 动脉粥样硬化斑块 疗效评价
分类号 R445.2 [医药卫生—影像医学与核医学]
  • 相关文献

参考文献6

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共引文献10

同被引文献48

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引证文献3

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中国老年学杂志
2013年 第8期

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